Prevalence of anemia and quality of life in patients with rifampicin-resistant/ multi-drugs resistance tuberculosis treated with a short-term regimen

Nguyen Thi Lien Ha, Vu Quoc Dat, Nguyen Binh Hoa, Gregory Fox

Main Article Content

Abstract

The emergence of multidrug-resistant tuberculosis significantly complicates efforts to control the global tuberculosis epidemic. This study aims to evaluate the prevalence of anemia and the quality of life in patients with Rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) treated with short-term regimens in Vietnam. This descriptive, retrospective study included 544 tuberculosis patients diagnosed with confirmed Rifampicin resistance or multidrug-resistant tuberculosis, receiving short-term treatment at 35 medical facilities in the Drug-Resistant Tuberculosis Management Program across 7 provinces in Vietnam. The proportion of patients with anemia was 38.72% (211/544). The rates of mild, moderate, and severe anemia were 65.4%; 28.9% and 5.7%, respectively. In anemic patients, scores decreased in the components of role emotional - RE (35.5) and physical functioning - PF (38.1). The comprehensive assessment, early detection, and timely treatment of anemia are necessary to improve patients' quality of life.

Article Details

References

1. World Health Organization. Global Tuberculosis Report 2022. Geneva. 16 Jul, 2024. https://www.who.int/teams/global-tuber culosis-programme/tb-reports/global-tuberculo sis-report-2022
2. World Health Organization. Global Tuberculosis Report 2022. 2022. doi:https://www.who.int/teams/global-tuberculosis-progra mme/tb-reports/global-tuberculosis-report-2022
3. Demitto FO A-PM, Schmaltz CA, Sant’Anna FM, et al. Impact of persistent anemia on systemic inflammation and tuberculosis outcomes in persons living with HIV. Front Immunol [Internet]. 2021;11. doi:https://doi.org/10.3389/fimmu.2020.588405/full#B11
4. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Published online https://appswhoint/iris/handle/10665/85839. 2011 ;
5. Barzegari S AM, Movahednia M, Moosazadeh M. Prevalence of anemia among patients with tuberculosis: A systematic review and meta-analysis. Indian J Tube. 2019;66(2):299-307.
6. Bahi G, A Bamba, M’Boh G, et al. Evaluation of the Hematological and Biochemical Markers of Iron Metabolism in Pulmonary Multidrug-Resistant Tuberculosis (MDR-TB). J Trop Med Health. 2018;132. doi: 10.29011/JTMH-132. 0000322018;
7. Gelaw Y GZ, Melku M. Anemia as a risk factor for tuberculosis: A systematic review and meta-analysis. Environ Health Prev Med. 2021;26(1):13.
8. Wouters HJCMvdK, Melanie M, de Witte Theo, et al. Association of anemia with health-related quality of life and survival: A large population-based cohort study. Haematologica. 2019;104(3):468-476.
9. Bộ Y tế. Cập nhật hướng dẫn điều trị bệnh Lao kháng thuốc Ban hành kèm theo Quyết định số 2760/QĐ-BYT ngày 03/6/2021 của Bộ trưởng Bộ Y tế. 2021;
10. Watkins RE, Plant AJ, Sang D, et al. Development of a Vietnamese version of the Short form-36 Health Survey. Asia-Pacific journal of public health. 2000;12(2):118-23. doi:10.1177/101053950001200211
11. Maruish MEE. User’s manual for the SF-36v2 Health Survey (3rd ed.). Lincoln, RI: QualityMetric Incorporated. 2011;
12. Irbah SNP, A Pratiwi, Vidiast F, et al. The impact of anemia in prolong culture conversion amongs MDR-TB patients in persahabatan hospital Indonesia. International Journal of Infectious Diseases. 2019;79:91. doi:https://doi.org/10.1016/j.ijid.2018.11.228
13. Kreuzer KA RJ. Pathogenesis and pathophysiology of anemia in HIV infection. Ann Hematol. 1997;75(5-6):179 - 187. doi: 10.1007/s002770050340.
14. Shah AR, Desai KN, Maru AM. Evaluation of hematological parameters in pulmonary tuberculosis patients. Journal of Family Medicine and Primary Care. 2022;11(8):4424-4428. doi:10.4103/jfmpc.jfmp c_2451_21
15. Nguyet NTM, Nga NTQ. Prevalence of anemia and hematological characterisitics in patients with pulmonary tuberculosis at Danang Lung hospital. Vietnam Journal of Community Medicine. 2023;64(Special Issue 9):98-106.
16. Isanaka S, Mugusi F, Urassa W, et al. Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis123. The Journal of Nutrition. 2012;142(2):350-357. doi:https://doi.org/10.3945/jn.111.144287
17. Võ Trọng Thành. Nghiên cứu sự thay đổi một số chỉ số huyết học ở bệnh nhân lao phổi được điều trị tại bệnh viện phổi trung ương. Luận án Tiến sỹ. Trường Đại học Y Hà Nội; 2019.
18. Kim Y-J, Han KD, Cho K-H, et al. Anemia and health-related quality of life in South Korea: data from the Korean national health and nutrition examination survey 2008 - 2016. BMC Public Health. 2019;19(1):735. doi:10.1186/s12889-019-6930-y
19. Kraai IH LM, Johansson P, De Jong RM, et al. Health-related quality of life and anemia in hospitalized patients with heart failure. Int J Cardiol. 2012;161(3):151-5.