The effect of topical “D2-VDN” on wound healing in Swiss albino mice

Pham Thi Van Anh, Tran Thi Hong Phuong, Nguyen Thi Thanh Loan, Nguyen Thi Thanh Ha

Main Article Content

Abstract

 Virgin coconut oil has been shown to possess numerous effects, including antioxidant, skin-softening, antibacterial, anti-inflammatory and enhanced epithelialization. “D2-VDN” consists of virgin coconut oil sourced from Vietnam and promises to effectively treat skin damage. The project aims to experimentally evaluate the wound healing effect of "D2-VDN," conducted on Swiss albino mice with skin wounds. The research drugs included: Contractubex applied topically at a dose of 0.2 g/day, and "D2-VDN" applied topically at doses of 0.2 ml/day and 0.4 ml/day, for 14 consecutive days. “D2-VDN” accelerates the wound healing process on mice skin by reducing the lesion area and improving the histopathology of the damaged skin (p < 0.05).

Article Details

References

1. Hajiaghaalipour F, Kanthimathi MS, Abdulla MA, et al. The Effect of Camellia sinensis on Wound Healing Potential in an Animal Model. Evid Based Complement Alternat Med. 2013;2013:386734. doi: 10.1155/2013/386734.
2. S M, Firdous, Sautya, et al. Medicinal plants with wound healing potential. Bangladesh Journal of Pharmacology. 2018;13. doi: 41. 10. 3329/bjp.v13i1.32646.
3. R A Govindarajan, P Pushpangadan, B Kumara, et al. Ethno-pharmacological approaches to wound healing-exploring medicinal plants of India. Journal of Ethnopharmacology. 2007; 114: 103–113.
4. J D Phillipson. Phytochemistry and medicinal plants. Phytochemistry. 2001;56(3):237-243.
5. Fernandes A, Rodrigues PM, Pintado M, et al. A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging. Phytomedicine. 2023;115:154824. doi:10.101 6/j.phymed.2023.154824.
6. Ibrahim AH, Li H, Al-Rawi SS, et al. Angiogenic and wound healing potency of fermented virgin coconut oil: in vitro and in vivo studies. Am J Transl Res. 2017;9(11):4936-4944. PMID: 29218091; PMCID: PMC5714777.
7. Stegemann H, Stalder K. Determination of hydroxyproline. Clin Chim Acta. 1967;18(2):267-73. doi: 10.1016/0009-8981(67)90167-2. PMID: 4864804.
8. Wang, Peng-Hui, Huang, et al. Wound healing. Journal of the Chinese Medical Association. 2017;81:94-101. doi: 10.1016/j.jc ma.2017.11.002.
9. Srivastava AK, Khare P, Nagar HK, et al. Hydroxyproline: A Potential Biochemical Marker and Its Role in the
Pathogenesis of Different Diseases. Curr Protein Pept Sci. 2016;17(6):596-602. doi:10.2174/1389203717666151201192247
10. Ozay R, Keskin E, Balkan MS, et al. Effects of Topically Applied Contractubex® on Epidural Fibrosis and Axonal Regeneration in Injured Rat Sciatic Nerve. Turk Neurosurg. 2023;33(3):437-446. doi:10.5137/1019-5149.JTN.40989-22.2
11. Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017;19(1):70. Published 2017 Dec 27. doi:10.3390/ijms19010070
12. Istek O, Tanrisever M, Kucukler S, et al. Comparison of the effects of Aloe vera gel and coconut oil on the healing of open wounds in rats. Vet Med (Praha). 2023;68(1):17-26. Published 2023 Jan 13. doi:10.17221/101/2021-VETMED