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Published: 2024-09-27
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DOI: https://doi.org/10.52852/tcncyh.v181i8.2717
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Vol. 181 No. 8 (2024)
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Các bài báo
How to Cite
Thuý, H. T., & Chính, P. C. (2024). 12. Efficacy of intralesional injection of Triamcinolone Acetonide and Botulinum toxin combination in the treatment of keloids. Journal of Medical Research, 181(8), 113-120. https://doi.org/10.52852/tcncyh.v181i8.2717

12. Efficacy of intralesional injection of Triamcinolone Acetonide and Botulinum toxin combination in the treatment of keloids

Hoang Thi Thuy, Pham Cong Chinh

Main Article Content

Abstract

The study aimed to evaluate the outcomes of treating keloids using intralesional injections of Triamcinolone acetonide (TAC) combined with Botulinum toxin A (BTA). This uncontrolled trial was conducted on 26 patients with 49 keloid scars. Before treatment, the average scar thickness was 1.86 ± 0.76, the hardness was 3 ± 0.84, and the total VSS (Vancouver Scar Score) was 7.53 ± 2.22. After treatment, these values were reduced to 0.43 ± 0.65, 0.53 ± 0.65, and 4.29 ± 2.82, respectively (p < 0.05). The average pigmentation score before treatment was 3 ± 0.84 and the vascularity score was 2.02 ± 0.80, which increased to 1.02 ± 1.01 and 2.33 ± 0.94, respectively, after treatment (p < 0.05). The average POSAS (Patient and Observer Scar Assessment Scale) score from the observer was 31.02 ± 7.40 before treatment and 14.29 ± 4.96 after treatment (p < 0.05), while the patient’s self-assessment scores were 37.45 ± 9.59 and 14.16 ± 4.75, respectively (p < 0.05). The average improvement rate of scar thickness after treatment was 79.93% ± 29.65%, with 63.3% of the scars flattened completely. Our study shows that the treatment of keloid scars with a combination of TAC and BTA injections is highly effective, significantly reducing functional symptoms and scar thickness, while also achieving a high rate of patient satisfaction.

Article Details

Keywords

Keloid, Triamcinolone acetonide, Botulinum toxin A, Treatment of keloids

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