Evaluation of antitussive and expectorant activities of “thuoc ho bo phoi Abipha” liquid extract
Main Article Content
Abstract
The purpose of this study was to evaluate antitussive and expectorant activities of “Thuốc ho bổ phổi Abipha” on Swiss mice. The antitussive effect of “Thuốc ho bổ phổi Abipha” liquid extract was measured using a murine model of ammonia-induced cough. The expectorant effect of “Thuốc ho bổ phổi Abipha” liquid extract was evaluated by measuring mice's tracheal phenol red output. “Thuốc ho bổ phổi Abipha” liquid extract at both doses of 9 mL/kg and 18 mL/kg significantly inhibited the cough frequency, increased the inhibition of cough, and increased the latent period of cough. In terms of expectorant effect, “Thuốc ho bổ phổi Abipha” at both doses of 9 mL/kg and 18 mL/kg significantly improved mice's tracheal phenol red output as compared with the control group. In conclusion, “Thuốc ho bổ phổi Abipha” was a product derived from herbal medicine, and posed remarkable antitussive, expectorant effects in the experiment.
Article Details
Keywords
“Thuốc ho bổ phổi Abipha”, antitussive, expectorant, Swiss mice
References
2. Yu P, Cheng S, Xiang J, et al. Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus. J Ethnopharmacol. 2015; 164: 328-333. doi:10.1016/j.jep.2015.02.036.
3. Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2020; 8(6):585-596. doi:10.1016/S2213-2600(20)30105-3.
4. Kraft K. The importance of herbal antitussives and expectorants. Pharm Unserer Zeit. 2008; 37(6): 478-483. doi:10.1002/pauz.200800287.
5. Wu F, Tian M, Sun Y, et al. Efficacy, chemical composition, and pharmacological effects of herbal drugs derived from Fritillaria cirrhosa D. Don and Fritillaria thunbergii Miq. Front Pharmacol. 2022; 13:985935. doi:10.3389/fphar.2022.985935.
6. Liu Q, Lu JJ, Hong HJ, et al. Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms. Phytomedicine. 2023; 113:154718. doi:10.1016/j.phymed.2023.154718.
7. Dapaah G, Koffuor GA, Mante PK, et al. Antitussive, expectorant and analgesic effects of the ethanol seed extract of Picralima nitida (Stapf) Th. & H. Durand. Res Pharm Sci. 2016 Mar-Apr; 11(2):100-12. https://pubmed.ncbi.nlm.nih.gov/27168749/.
8. Hu JR, Jung CJ, Ku SM, et al. Antitussive, expectorant, and anti-inflammatory effects of Adenophorae Radix powder in ICR mice. J Ethnopharmacol. 2019; 239:111915. doi:10.1016/j.jep.2019.111915.
9. Hock FJ. Drug Discovery and Evaluation: Pharmacological Assays, Fourth Edition.; 2015:4314. doi:10.1007/978-3-319-05392-9.
10. Plevkova J, Brozmanova M, Matloobi A, et al. Animal models of cough. Respir Physiol Neurobiol. 2021; 290:103656. doi:10.1016/j.resp.2021.103656.
11. Zhang C, Lin RL, Hong J, et al. Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice. Am J Physiol - Regul Integr Comp Physiol. 2017; 312(5):R718-R726. doi:10.1152/ajpregu.00444.2016.
12. Nosalova G, Mokry J and Franova S. Pharmacological modulation of cough reflex. Adv Phytomedicine. 2006; 2:87-110. doi:10.1016/S1572-557X(05)02006-4.
13. Kantar A, Klimek L, Cazan D, et al. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. Multidiscip Respir Med. 2020;15(1):511. doi:10.4081/mrm.2020.511.
14. Simayi Z, Rozi P, Yang X, et al. Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review. Int J Biol Macromol. 2021; 183: 387-398. doi:10.1016/j.ijbiomac.2021.04.099.
15. Đỗ Tất Lợi. Những Cây Thuốc và vị Thuốc Việt Nam. Nhà xuất bản Hà Nội; 2015, 715-716, 837-841.