Desmoid fibromatosis of the breast: A case report and literature review
Main Article Content
Abstract
Desmoid Fibromatosis (DF) is a soft tissue tumor that aggressive locally but does not metastasize, often occurring in the mesentery, abdominal wall and extremities. DF of the breast is very rare, accounting for only 0.2% of breast tumors. The disease has symptoms very similar to breast cancer in clinical and imaging diagnosis, and has a high recurrence rate. This is a case of a female patient, 50 years old, with a left breast mass. Ultrasound and mammography of the mammary gland suspected as a malignant tumor, classified as BIRADS 5. Preoperative biopsy results as a cytologically bland spindle cell tumor, positive for Beta-Catenin, SMA, Ki67 (1%); negative for pan-CK, ER and p63 markers. The preoperative diagnosis was Desmoid Fibromatosis. Diagnosis after surgery confirmed it was Desmoid Fibromatosis, with positive resection margin. In summary, DF of the breast is a borderline mesenchymal, rare, recurrent tumor that is easily confused with cancer clinically, requires diagnosis based on histopathology, and requires extensive surgery.
Article Details
Keywords
Desmoid Fibromatosis, Breast cancer, Local recurrence, Beta-Catenin
References
2. Ioannidis, C. Extra abdominal desmoid tumor (fibromatosis) of the breast. Hellenic Journal of Obstetrics & Gynecology ISSN. 2018, 2241, 9276.
3. Neuman HB, Brogi E, Ebrahim A, Brennan MF, Van Zee KJ. Desmoid tumors (fibromatoses) of the breast: a 25-year experience. Ann Surg Oncol. 2008; 15(1): 274–280.
4. CHOI, Joon Hyuk; RO, Jae Y. The 2020 WHO classification of tumors of soft tissue: selected changes and new entities. Advances in Anatomic Pathology. 2021, 28.1: 44-58.
5. Lacroix-Triki M, et al. β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol. 2010; Nov; 23(11): 1438-48.
6. Ha Ky, Deleon P, Hamilton R. Breast fibromatosis mimicking breast carcinoma. Proc (Bayl Univ Med Cent).2013; 26: 22-24.
7. Boland, Michael R., et al. Fibromatosis of the breast: a 10-year multi-institutional experience and review of the literature. Breast Cancer. 2021; 28: 168-174.
8. Lorenzen, Jörn, et al. Desmoid type fibromatosis of the breast: ten-year institutional results of imaging, histopathology, and surgery. Breast Care. 2021, 16.1: 77-84.
9. Kangas-Dick, Aeryn, et al. Diagnosis and Management of Desmoid Fibromatosis of the Breast. World Journal of Oncology.2024;15.3: 394.
10. Duazo-Cassin, Ludwig, et al. Breast desmoid tumor management in France: toward a new strategy. Breast cáncer Research and Treatment. 2019, 176: 329-335.