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Published: 2024-11-11
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DOI: https://doi.org/10.52852/tcncyh.v183i10.2911
Issue
Vol. 183 No. 10 (2024)
Section
Các bài báo
How to Cite
Giang, Đặng T. K., & Khánh, N. N. (2024). Glucose metabolism disorders in obese children. Journal of Medical Research, 183(10), 140-146. https://doi.org/10.52852/tcncyh.v183i10.2911

Glucose metabolism disorders in obese children

Dang Thi Kim Giang, Nguyen Ngoc Khanh

Main Article Content

Abstract

Obesity is a pathological condition characterized by abnormal or excessive fat deposits that can impair health including insulin resistance and glucose metabolism disorders. We studied on 437 children with age of 5-18 years diagnosed obesity at the Vietnam National Children’s Hospital from June 2023 to June 2024 by cross-sectional descrption, retrospective, with objective: “Describe glucose metabolism disorder in obese children”. In our corhort, the male: female ratio was 64.3:35.7 (1.8:1); the group of children with age of 5 - 10 years accounting for 70.02%. The body mass index (BMI) according to Z-score of boys was 3.19 ± 1.24, higher than that of girls at 2.78 ± 0.66 (p = 0.00017). The rate of children with acanthosis nigricans was 49.88%, the rate of hyperinsulinemia was 32.2%. The rate of prediabetes 31.08%, type 2 diabetes mellitus was 1.2%.

Article Details

Keywords

Obesity, acanthosis nigricans, insulin resistance, glucose metabolism disorders, children

References

1. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. 1 March 2024
2. Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377(9765):557-567. doi:10.1016/S0140-6736(10)62037-5.
3. Di Cesare M, Sorić M, Bovet P, et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Med. 2019; 17(1):212. Published 2019 Nov 25. doi:10.1186/s12916-019-1449-8.
4. World Health Organization (WHO). Global database on child health and malnutrition. UNICEF-WHO-The World Bank: Joint child malnutrition estimates - Levels and trends. Geneva: WHO; 2019. http://www.who.int/
5. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017; 390(10113): 2627-2642. doi:10.1016/S0140-6736(17)32129-3.
6. Koh YK, Lee JH, Kim EY, et al. Acanthosis Nigricans as a Clinical Predictor of Insulin Resistance in Obese Children. Pediatr Gastroenterol Hepatol Nutr. 2016; 19(4):251-258. doi:10.5223/pghn.2016.19.4.251.
7. Linh NT, Phương LT và Phượng DT Thực trạng thừa cân béo phì và bữa ăn học đường của học sinh một trường tiểu học tại Hà Nội năm 2017 và 2018. Tạp chí Dinh dưỡng và Thực phẩm. 2018. 14(2): p. 35-42.
8. Nuha AE, Grazia A, Vanita RA, et al, American Diabetes Association; 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care 1 January 2023; 46 (Supplement_1): S19–S40. https://doi.org/10.2337/dc23-S002.
9. Anh BTK, Trung LT và Tuân LV. Mối liên quan giữa tiêu thụ thức uống có đường và thừa cân ở học sinh Thành phố Hồ Chí Minh. Y học TP. Hồ Chí Minh. 2022; 26(2): 354-362.
10. Hồng PTK và Tâm PT. Nghiên cứu tình hình thừa cân, béo phì và các yếu tố liên quan ở học sinh tại các trường tiểu học thành phố Bến Tre, tỉnh Bến Tre năm 2018. Tạp chí Y dược học Cần Thơ. 2019; 19: 1-9.
11. Iwani NA, Jalaludin MY, Zin RM, et al. Triglyceride to HDL-C Ratio is Associated with Insulin Resistance in Overweight and Obese Children. Sci Rep. 2017; 7:40055. Published 2017 Jan 6. doi:10.1038/srep40055.
12. Yamazaki H, Ito S, Yoshida H. Acanthosis nigricans is a reliable cutaneous marker of insulin resistance in obese Japanese children. Pediatr Int. 2003; 45(6): 701-705. doi:10.1111/j.1442-200x.2003.01812.x.
13. Guran T, Turan S, Akcay T, et al. Significance of acanthosis nigricans in childhood obesity. J Paediatr Child Health. 2008; 44(6): 338-341. doi:10.1111/j.1440-1754.2007.01272.x.
14. Ng HY, Young JH, Huen KF, et al. Acanthosis nigricans in obese Chinese children. Hong Kong Med J. 2014; 20(4): 290-296. doi:10.12809/hkmj134071.
15. Abraham C & Rozmus CL. Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review. J Sch Nurs. 2012; 28(3): 195-205. doi:10.1177/1059840511430952.
16. Gutch M, Kumar S, Razi SM, et al. Assessment of insulin sensitivity/resistance. Indian J Endocrinol Metab. 2015; 19(1): 160-164. doi:10.4103/2230-8210.146874.
17. Hoa NT. Đặc điểm bệnh nhân béo phì và hiệu quả điều trị béo phì tại khoa Dinh dưỡng bệnh viện Nhi Đồng I (1998-2008). Tạp chí Dinh dưỡng và Thực phẩm. 2010, 6(3+4): p. 127-129.