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Published: 2025-01-10
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DOI: https://doi.org/10.52852/tcncyh.v186i1.2978
Issue
Vol. 186 No. 1 (2025)
Section
Các bài báo
How to Cite
Ngọc, N. T. B. ., Phương, P. T. ., Ngọc, V. P. ., Lâm, T. V. ., Vân Anh, P. T. ., Hạnh, H. M., Trung, L. H., & Dương, Đậu T. . (2025). Anti-peptic ulcer effect of Da day Phuong Dong hard capsules in experiments. Journal of Medical Research, 186(1), 254-262. https://doi.org/10.52852/tcncyh.v186i1.2978

Anti-peptic ulcer effect of Da day Phuong Dong hard capsules in experiments

Nguyen Thi Bich Ngoc, Pham Thuy Phuong, Vu Phuong Ngoc, Trinh Vu Lam, Pham Thi Van Anh, Hoang My Hanh, Le Hai Trung, Dau Thuy Duong

Main Article Content

Abstract

Da day Phuong Dong hard capsule is a combination of medicinal herbs with the purpose of treating peptic ulcers. The objective of this study is to evaluate the effect of Da day Phuong Dong on the model of indomethacin-induced peptic ulcers. Wistar rats were divided into five groups and given orally distilled water (biological control group, model group), misoprostol (positive control group), Da day Phuong Dong at 0.48 tablets/kg/day and 1.44 tablets/kg/day for seven consecutive days, followed by oral administration of indomethacin ata single dose of 40 mg/kg. Six hours after indomethacin administration, rats were dissected to evaluate the macroscopic and microscopic appearance of the stomach and duodenum. Our results showed that Da day Phuong Dong reduced the ulcer index when compared to the model group. The ulcer inhibition rate was 36.36% and 18.18% in 0.48 tablets/kg-treated group and 1.44 tablets/kg-treated group, respectively. Da day Phuong Dong also improved pathological images compared to the model group. In summary, Da day Phuong Dong has the effect of preventing indomethacin-induced gastroduodenal ulcers in experiment rats.

Article Details

Keywords

Gastroduodenal ulcers, indomethacin, Da day Phuong Dong, Wistar rats

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