7. Relationship between mpv and therapeutic effect of methylprednisolone in patients with immune thrombocytopenia
Main Article Content
Abstract
To determine the relationship between the mean platelet volume (MPV) and the treatment efficacy of methylprednisolon in patients with primary immune thrombocytopenia (ITP) a descriptive correlation study was conducted on 76 ITP patients treated with standard-dose methylprednisolon at Military Hospital 103 from September in 2019 to September in 2024. The number of responders (complete responders was 42.1%) and non-responders were 71.1% and 28.9%, respectively. The mean of MPV in the complete responders or responders were higher compared to non-responders, with p = 0.001 and p = 0.014, respectively. The cut-off value of MPV for predicting treatment response with methylprednisolone was 9.85fL, the area under the curve (AUC) was 0.726, with p = 0.002. In predicting treatment response to methylprednisolone, the MPV index's sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 75.9%, 59.1%, 82%, 50%, and 71.1%, respectively. For patients with ITP, the MPV can be used to predict how well they will respond to standard-dose methylprednisolone.
Article Details
Keywords
Primary Immune Thrombocytopenia, Mean Platelet Volume, Military Hospital 103
References
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