Clinical and paraclinical characteristics of community bacteremia in childen

Do Thien Hai, Nguyen Van Lam

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Abstract

Bacteremia is the leading cause of death in children worldwide. This study describes clinical and paraclinical characteristics of community-acquired bacteremia in children treated at the Center for Tropical Diseases, National Children's Hospital from January 2019 to December 2021. In 79 pediatric patients the average age was 11.5 (4.2 - 35.3) months old, with the incidence decreasing as children grew older. The male/female ratio was 1/1.54. Symptoms of infection in the soft tissue (32.91%, digestive (31.65%), respiratory (29.11%), and nervous (27.85%) organs included the following symptoms: diarrhea (21.5%), meningeal signs (25.3%), diffuse soft tissue inflammation (26.6%), and respiratory tract inflammation-respiratory failure (26.6%). Anemia accounted for 38%, abnormal white blood cells (increase - decrease) was 91.1%, increased CRP concentration > 15 mg/L accounted for 96.2%. The rate of septic shock was 5.1%.

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References

1. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Feb 2020;21(2):e52-e106. doi:10.1097/pcc.0000000000002198
2. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. Mar 2018;6(3):223-230. doi:10.1016/s2213-2600(18)30063-8
3. Morin L, Ray S, Wilson C, et al. Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition. Intensive Care Med. Dec 2016;42(12):1948-1957. doi:10.1007/s00134-016-4574-2
4. Weiss SL, Balamuth F, Hensley J, et al. The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Sep 2017;18(9):823-830. doi:10.1097/pcc.0000000000001222
5. Humoodi MO, Aldabbagh MA, Salem MM, et al. Epidemiology of pediatric sepsis in the pediatric intensive care unit of king Abdulaziz Medical City, Jeddah, Saudi Arabia. BMC Pediatrics. 2021/05/07 2021;21(1):222. doi:10.1186/s12887-021-02686-0
6. Balamuth F, Weiss SL, Neuman MI, et al. Pediatric severe sepsis in U.S. children’s hospitals. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Nov 2014;15(9):798-805. doi:10.1097/pcc.0000000000000225
7. Schaffner J, Chochua S, Kourbatova EV, et al. High mortality among patients with positive blood cultures at a children’s hospital in Tbilisi, Georgia. Journal of infection in developing countries. May 1 2009;3(4):267-72. doi:10.3855/jidc.123
8. Hương TTT, An PN. Nghiên cứu đặc điểm dịch tễ học lâm sàng bệnh nhiễm khuẩn huyết tại khoa truyền nhiễm Bệnh viện Nhi Trung ương. Tạp chí Y học Việt Nam. 2013;2(2):117-122.
9. Zallocco F, Osimani P, Carloni I, et al. Assessment of clinical outcome of children with sepsis outside the intensive care unit. European journal of pediatrics. Dec 2018;177(12):1775-1783. doi:10.1007/s00431-018-3247-2
10. Agyeman PKA, Schlapbach LJ, Giannoni E, et al. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. The Lancet Child & adolescent health. Oct 2017;1(2):124-133. doi:10.1016/s2352-4642(17)30010-x
11. Ree IMC, Fustolo-Gunnink SF, Bekker V, et al. Thrombocytopenia in neonatal sepsis: Incidence, severity and risk factors. PloS one. 2017;12(10):e0185581. doi:10.1371/journal.pone.0185581
12. Sorsa A. Epidemiology of Neonatal Sepsis and Associated Factors Implicated: Observational Study at Neonatal Intensive Care Unit of Arsi University Teaching and Referral Hospital, South East Ethiopia. Ethiopian journal of health sciences. May 2019;29(3):333-342. doi:10.4314/ejhs.v29i3.5