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Published: 2025-03-26
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DOI: https://doi.org/10.52852/tcncyh.v188i3.3162
Issue
Vol. 188 No. 3 (2025)
Section
Các bài báo
How to Cite
Tuệ, N. T., & Trâm Anh, L. T. . (2025). Study on the effects of sleep deprivation and ethanol use on human health using drosophila models. Journal of Medical Research, 188(3), 1-9. https://doi.org/10.52852/tcncyh.v188i3.3162

Study on the effects of sleep deprivation and ethanol use on human health using drosophila models

Nguyen Trong Tue, Le Thi Tram Anh

Main Article Content

Abstract

Alcohol abuse and the prevalence of sleep disorders among young people due to various causes have led to significant health, mental, and quality-of-life issues. Since 1930, numerous studies have focused on the effects of alcohol on sleep, but little is known about how sleep impacts alcohol toxicity. Given that the sleep and alcohol physiology of fruit flies share similarities with mammals, this study uses a fruit fly model to assess the effects of sleep deprivation on alcohol toxicity. Ten-day-old adult flies, after 24 hours of sleep deprivation via mechanical stimulation, were exposed to 70% ethanol vapor for 1 hour. Results showed that sleep deprivation increased sedation sensitivity (50% of flies sedated after 25 minutes compared to 40 minutes in the control group) and mortality due to ethanol (31.44% compared to 0.38% in the sleep-deprived-only group). Mortality rates in male and female flies increased to 35.33% and 36.22%, respectively. This research sheds light on the relationship between sleep deprivation and alcohol toxicity, providing a foundation for future preventive and therapeutic measures against alcohol-related disorders.

Article Details

Keywords

Sleep deprivation, Ethanol, Drosophila

References

1. M S Moore, J DeZazzo, A Y Luk, et al. Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell. 1998;93(6):997-1007. doi: 10.1016/s0092-8674(00)81205-2.
2. Hirshkowitz M, Whiton K, Albert SM, et al. National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health. 2015;1(1):40-43. doi:10.1016/j.sleh.2014.12.010
3. Brant P Hasler, Adriane M Soehner, Duncan B Clark. Sleep and circadian contributions to adolescent alcohol use disorder. Alcohol. 2015;49(4):377-87. doi: 10.1016/j.alcohol.2014.06.010.
4. Knutson KL, Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci. 2008;1129:287-304. doi:10.1196/annals.1417.033
5. Kenney SR, LaBrie JW, Hummer JF, et al. Global sleep quality as a moderator of alcohol consumption and consequences in college students. Addict Behav. 2012;37(4):507-512. doi:10.1016/j.addbeh.2012.01.006
6. Andretic R, Shaw PJ. Essentials of sleep recordings in Drosophila: moving beyond sleep time. Methods Enzymol. 2005;393:759-772. doi:10.1016/S0076-6879(05)93040-1
7. Karla R Kaun, Anita V Devineni, Ulrike Heberlein. Drosophila melanogaster as a model to study drug addiction. Hum Genet. 2012;131(6):959-975. doi: 10.1007/s00439-012-1146-6
8. Van der Linde K, Lyons LC. Circadian modulation of acute alcohol sensitivity but not acute tolerance in Drosophila. Chronobiol Int. 2011;28(5):397-406. doi:10.3109/07420528.2011.577921
9. De Nobrega AK, Mellers AP, Lyons LC. Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster. Exp Gerontol. 2017;97:49-59. doi:10.1016/j .exger.2017 .07.014
10. Gibson EM, Williams WP, Kriegsfeld LJ. Aging in the circadian system: considerations for health, disease prevention and longevity. Exp Gerontol. 2009;44(1-2):51-56. doi:10.1016/j.exger.2008.05.007
11. Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina SundquistAlcohol Use Disorder and Mortality Across the Lifespan. JAMA Psychiatry. 2016;73(6):575-81. doi: 10.1001/jamapsychiatry.2016.0360.
12. De Nobrega AK, Mellers AP, Lyons LC. Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster. Exp Gerontol. 2017;97:49-59. doi:10.1016/j.exger.2017.07.014
13. Erol A, Karpyak VM. Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations. Drug Alcohol Depend. 2015;156:1-13. doi:10.1016/j.drugalcdep.2015.08.023
14. Smith WB, Weisner C. Women and alcohol problems: a critical analysis of the literature and unanswered questions. Alcohol Clin Exp Res. 2000;24(8):1320-1321.
15. Nguyễn Trọng Tuệ, Nguyễn Thị Tuyết, Lê Thị Trâm Anh, và cs. Ảnh hưởng của ethanol lên quá trình sinh trưởng và phát triển trên mô hình ruồi giấm. Tạp chí Y học Việt Nam. 2023;(2):108-112.
16. Fernández-Solà J, Nicolás-Arfelis JM. Gender differences in alcoholic cardiomyopathy. J Gend-Specif Med JGSM Off J Partnersh Womens Health Columbia. 2002;5(1):41-47.