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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3216
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Vol. 191 No. 6 (2025)
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Huy, T. Q., Đại, H. Q., Phương, P. P. P., Yến, H. T. H., Sơn, N. T., Nguyên, L. P., Duyên, B. T. H., Biên, L. H. T., & Tú, N. N. (2025). Factors associated with mortality in patients with sepsis and metabolic acidosis by quantitative abg analysis. Journal of Medical Research, 191(6), 36-47. https://doi.org/10.52852/tcncyh.v191i6.3216

Factors associated with mortality in patients with sepsis and metabolic acidosis by quantitative abg analysis

Tran Quang Huy, Huynh Quang Dai, Pham Phan Phuong Phuong, Hoang Thi Hai Yen, Nguyen Thanh Son, Lam Phuoc Nguyen, Bui Thi Hanh Duyen, Le Huu Thien Bien, Nguyen Ngoc Tu

Main Article Content

Abstract

Metabolic acidosis is a common condition and a significant prognostic factor in patients with sepsis. However, this relationship is not linear and is believed to depend on the underlying mechanisms and clinical types of metabolic acidosis. This study aims to determine the prevalence of different clinical types of metabolic acidosis and the factors associated with mortality in patients with sepsis and metabolic acidosis through arterial blood gas analysis. This is a retrospective cohort study with longitudinal follow-up of patients with sepsis and metabolic acidosis admitted to the Intensive Care Unit (ICU) of the University Medical Center Ho Chi Minh City from June 2022 to June 2024. 563 sepsis patients were admitted to the hospital during the aforementioned time period, of which 128 sepsis patients were selected to be included in the study. The results showed that the prevalence of metabolic acidosis due to unmeasured anions accumulation was 46.1% at ICU admission, while lactic acidosis and hyperchloremic acidosis accounted for 23.4% and 25.8%, respectively. The rate of persistent metabolic acidosis lasting over 24 hours was 56.1%, predominantly due to unmeasured anions accumulation. Factors associated with mortality in patients with sepsis and metabolic acidosis included acute kidney injury with an OR of 5.76 (95% CI: 1.01 - 26.2). Both fixed acid metabolic acidosis and lactic acidosis were associated with increased mortality, with OR of 1.94 (95% CI: 1.11 - 3.4) and 1.86 (95% CI: 1.04 - 3.35), respectively.

Article Details

Keywords

Metabolic acidosis, sepsis, unmeasured anion

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