5. Single-nucleotide polymorphism rs2856718 of HLA-DQ gene on hepatitis C patients
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Abstract
Human leukocyte antigen (HLA) class II polymorphisms play a crucial role in antiviral immune responses and are associated with susceptibility to hepatitis C virus (HCV) infection. This study aimed to assess the association between the single nucleotide polymorphism (SNP) rs2856718 in the HLA-DQ gene and the risk of HCV infection, as well as certain clinical characteristics of HCV patients. Blood samples were collected from 101 HCV patients and 127 healthy controls, and the rs2856718 genotype was determined using the TaqMan Realtime-PCR method. The frequencies of the AA, GA, and GG genotypes were 21.8%, 45.5%, and 32.7% in the HCV group, respectively, compared to 19.7%, 48%, and 32.3% in the control group, with no statistically significant difference. However, the frequency of the AA genotype was significantly higher in HCV patients with ALT levels ≥ 41 U/L compared to those with ALT < 41 U/L (p = 0.041). These findings suggest that SNP rs2856718 in the HLA-DQ gene is not significantly associated with HCV susceptibility but may be related to serum alanine aminotransferase (ALT) levels in HCV-infected patients.
Article Details
Keywords
Hepatitis C virus infection, SNP rs2856718, HLA-DQ
References
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