15. Factors related to the treatment outcomes in patients with infective endocarditis

Ta Thi Dieu Ngan, Vu Phuong Nga, Nguyen Cong Huu

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Abstract

This retrospective study of 84 patients with infective endocarditis (IE) at the Cardiovascular Center of E Hospital from 2019 to 2024 was conducted to describe the treatment outcomes and factors related to the treatment outcomes in these patients. The results showed that, 82.1% of patients were initially treated with a combination of 2 antibiotics; 88.1% were treated with a combination of medical and surgical treatment. At the time of discharge, 94% had good progression and 6% had severe progression. Patients receiving combined medical-surgical treatment had a higher rate of good progression than patients receiving medical treatment alone (97.3% vs 70%; p < 0.05); patients treated with a combination of 2 antibiotics had higher rate of good progression than the single antibiotic treatment (97.1% vs 80.0%; p < 0.05). The rate of cerebral hemorrhage and high procalcitonin levels were significantly higher in the group with severe progression compared to the group with good progression. In conclusion, cerebral hemorrhage, high PCT levels are associated with severe progression, combined medical-surgical treatment and initial combination of antibiotic are associated with good progression in patients with IE.

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References

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