32. Evaluation of “da day hoan Ba Giang” ‘s effect on Cysteamine – induced peptic ulcer model
Main Article Content
Abstract
Peptic ulcer is a very common digestive tract disease. Da day hoan Ba Giang is a herbal combination intended to treat this disease. This study aimed to evaluate the effect of Da day hoan Ba Giang on the cysteamine-induced model of peptic ulcers in experimental animals. Wistar rats divided into 5 groups were orally given water (group 1, group 2), ranitidine (group 3) and Da day hoan Ba Giang (group 4) at a dose of 4.32 tablets/kg/day, respectively, for 10 consecutive days. One hour after the last dose, rats of groups 2 to 4 were induced peptic ulcers by oral cysteamine administration. Our results showed that Da day hoan Ba Giang reduced the ulcer rate, the average number of lesions, and the ulcer index and improved the microscopic image of the stomach and duodenum. In summary, Da day hoan Ba Giang at the dose of 4.32 tablets/kg/day has an anti-peptic ulcer effect on the cysteamine-induced peptic ulcer model in experimental animals.
Article Details
Keywords
Da day hoan Ba Giang, cysteamine, peptic ulcers, cysteamine, Wistar rats
References
2. Phạm Thị Minh Đức. Sinh lý học, Nhà xuất bản Y học; 2011,
3. Đào Văn Long. Bài tiết acid dịch vị và bệnh lý liên quan. Nhà xuất bản Y học; 2014.
4. Lanas, A.; Chan, F.K.L. Peptic ulcer disease. Lancet. 2017; 390: 613-624.
5. Subudhi, B.B.; Sahoo, S.P. Updates in Drug Development Strategies against Peptic ulcer. J. Gastrointest. Dig. Syst. 2016; 6; 398.
6. Roy AJ, Maut C, Gogoi HK et al. A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer. Curr Drug Discov Technol. 2023; 20(3):e121222211869.
7. Ahmed A. Elberry. Protective effect of sildenafil against cysteamine induced duodenal ulcer in Wistar rats. African Journal of Pharmacy and Pharmacology. 2013; Vol 7(33): 2352-2357.
8. Babak Rezvanjoo et al. Effects of Vitamin C and Melatonin on Cysteamine Induced Duodenal Ulcer in a Cholestatic Rat Model: A Controlled Experimental Study. Current Therapeutic Research. 2010; Volume 71, Number 5: 322-330.
9. Satapathy, Trilochan & Sen, Kalpana & Sahu, Shailesh et al. Experimental animal models for gastric ulcer / peptic ulcer: An overview. Journal of Drug Delivery and Therapeutics. 2024; 14: 182-192.
10. Adinortey, M.B.; Ansah, C.; Galyuon, I et al. A. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcer. 2013; 796405.
11. Duc Minh Nguyen, Quang Canh Tran, Minh Trung Do et al. Anti-Ulcer Activity of Spray-dried Powders Prepared from Aerial Parts Extracts of Ampelopsis cantoniensis. Pharmacognosy Journal. 2022; 14: 276-281.
12. Worapongpaiboon R, Kaikaew K, Werawatganone P, Somanawat K, Lerttanatum N, Klaikeaw N, Werawatganon D. Gardenia jasminoides fruit extract alleviates non-steroidal anti-inflammatory drug-induced gastropathy in rats. BMC Complement Med Ther. 2024; 24(1): 401.
13. Lee, Y.S., Kang, M.H., Cho, S.Y. et al. Effects of constituents of amomum anthioides on gastritis in rats and on growth of gastric cancer cells. Arch Pharm Res. 2007; 30: 436-443.
14. Suzuki H, Nishizawa T, Tsugawa H, Mogami S, Hibi T. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr. 2012; 50(1): 35-39.
15. Kuo-Ping Shen, Ching-Dong Chang, Meng-Hsun Hsieh et al. Efficency and mechanism evaluation of Magnolia officinalis water extract in preventing gastric ulcer. Evidence-Based Complementary and Alternative Medicine. 2023; 7901734.
16. Yan Yu, Tian-Zhu Jia, Qian Cai et al. Comparison of the anti-ulcer activity between the crude and bran-processed Atractylodes lancea in the rat model of gastric ulcer induced by acetic acid. Journal of Ethnopharmacology. 2023; Volume 160: 211-218.
17. Qingyao Li, Ting Lu, Xiaoyan Chen, Hongbiao Chu. Composition and Anti-ulcer Activity of the Essential Oil from Citri Reticulatae Pericarpium in Rodents. Brazilian Archives of Biology and Technology. 2023; Vol.66: e23210786.