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Published: 2025-08-29
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DOI: https://doi.org/10.52852/tcncyh.v193i8.3289
Issue
Vol. 193 No. 8 (2025)
Section
Các bài báo
How to Cite
Công, M. T. ., Quang, T. M., Liên, N. T. T. ., & Hằng, M. T. . (2025). Comparison of clinical and immunological characteristics of pediatric lupus patients with and without nephritis. Journal of Medical Research, 193(8), 387-394. https://doi.org/10.52852/tcncyh.v193i8.3289

Comparison of clinical and immunological characteristics of pediatric lupus patients with and without nephritis

Mai Thanh Cong, Ta Minh Quang, Nguyen Thị Thuy Lien, Mai Thi Hang

Main Article Content

Abstract

A cross-sectional study was conducted on 83 children newly diagnosed with systemic lupus erythematosus (SLE) at the Pediatric Center of Bach Mai Hospital - 53 with nephritis, 30 without nephritis - to compare the clinical and immunological characteristics between the two groups. The lupus nephritis group showed significantly higher rates of mucocutaneous manifestations (58.5%), serositis (28.3%), anti-dsDNA antibody positivity (100%), and hypocomplementemia (98.1%) compared to the non-nephritis group (33.3%, 10.0%, 86.7%, and 76.7%, respectively), p < 0.05. The mean EULAR/ACR 2019 classification criteria score was significantly higher in the lupus nephritis group than in the non-nephritis group (28.1 ± 5.5 vs 16.9 ± 4.2, p < 0.05). There were no significant difference between the two groups in terms of age, gender, fever, hematological, neurological, joint manifestations, anti-Smith antibody positivity, or antiphospholipid antibody positivity.

Article Details

Author Biography

Mai Thanh Cong,

Bộ môn Nhi trường Đại học Y Hà Nội

Keywords

Clinical, immunological, nephritis lupus, lupus, children

References

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