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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3300
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Vol. 191 No. 6 (2025)
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Các bài báo
How to Cite
Điển, T. M., Vân, Đặng T. H., & Anh, N. T. H. (2025). Comparison of Clinical and Paraclinical Features in Preterm Infants with Bronchopulmonary Dysplasia with and without Pulmonary Hypertension. Journal of Medical Research, 191(6), 326-334. https://doi.org/10.52852/tcncyh.v191i6.3300

Comparison of Clinical and Paraclinical Features in Preterm Infants with Bronchopulmonary Dysplasia with and without Pulmonary Hypertension

Tran Minh Dien, Dang Thi Hai Van, Nguyen Thi Hai Anh

Main Article Content

Abstract

Pulmonary hypertension (PH) is a common and serious cardiovascular complication in preterm infants with bronchopulmonary dysplasia (BPD). A prospective descriptive study was conducted on 292 preterm infants with BPD at the Neonatal Center, Vietnam National Children’s Hospital, from January 2022 to August 2024, we compare the clinical and paraclinical characteristics between preterm infants with and without PH. Echocardiography at 28 days of age revealed a PH prevalence of 15.4%. The results showed that the PH group had a lower gestational age and birth weight compared to the non-PH group. Multivariate logistic regression identified two predictors of PH in BPD: invasive mechanical ventilation until 28 days of age (OR = 5.299; 95%CI: 2.39 - 11.75) and history of shock (OR = 5.083; 95%CI: 2.37 - 10.91). The PH group had a longer duration of invasive mechanical ventilation, a higher incidence of ventilator-associated pneumonia. The mortality rate at the neonatal center was 28.9% in the PH group and 4.5% in the non-PH group. Preterm infants with PH and BPD have a lower gestational age, more severe and prolonged respiratory failure, and worse outcomes compared to those without PH.

Article Details

Keywords

Pulmonary hypertension, bronchopulmonary dysplasia, preterm infants

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