28. Assessment of Fibrinogen level variations in breast cancer patients
Main Article Content
Abstract
Breast cancer poses a significant risk to women's health. Fibrinogen serves as a factor that not only accelerates the proliferation of cancer cells but also facilitates metastasis. Consequently, variations in Fibrinogen levels are additional details for evaluating treatment prognosis and assessing metastasis in patients with breast cancer. This study employed a cross-sectional descriptive design, analyzing medical records from 105 breast cancer patients who were diagnosed and treated at Da Nang Oncology Hospital. The incidence of changes in Fibrinogen levels was found to be 11.4%. A correlation exists between elevated Fibrinogen levels and age. The established cut-off point for Fibrinogen concentration in individuals aged 50 years or younger, as well as those older than 50, is ≤ 2.87 g/l (AUC = 0.614). Furthermore, the cut-off point for Fibrinogen concentration in relation to the extent of metastasis is ≤ 3.27 g/l (AUC = 0.675), with a statistically significant difference noted (p < 0.05). Elevated Fibrinogen levels are referred markers for predicting the extent of metastasis in breast cancer patients.
Article Details
Keywords
Coagulation disorders in breast cancer patients, Fibrinogen
References
2. Tas F, Kilic L, Duranyildiz D. Coagulation tests show significant differences in patients with breast cancer. Tumor Biol. 2014; 35:5985-5992.
3. Amrani DL. Regulation of Fibrinogen biosynthesis: glucocorticoid and interleukin-6 control. Blood Coagul Fibrinolysis. 1990; 1(4–5): 443-446. PMID:2133221.
4. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005; 3(8): 1894-1904. PMID:16102057.
5. Simpson-Haidaris PJ, Rybarczyk B. Tumors and Fibrinogen: The role of Fibrinogen as an extracellular matrix protein. Ann N Y Acad Sci. 2001; 936: 406-425. PMID:11460495.
6. Ahmed T, Ahmed RS, Basharat MU, et al. Comparative study to assess coagulation abnormalities in breast cancer. Adv Life Sci. 2014; 1(2): 96-103.
7. Liu Z, Zhang N, Zhao Z, et al. The correlation between homocysteine, blood coagulation, and the breast cancer risk and clinicopathological characters: A case-control study. Res Cancer. 2022; 2693-5051.
8. Almothaffa A. Evaluation of D-dimer and Fibrinogen in breast cancer patients. Fellowship of the Medical Specialties Council in Pathology (Hematology) of Iraq. 2014.
9. Liu S, Fang J, Jiao D, Liu Z. Elevated platelet count predicts poor prognosis in breast cancer patients with supraclavicular lymph node metastasis. Cancer Manag Res. 2020; 6069-6075.
10. Ngọc TB, Giang LTH, Giang NK, Phương CTM. Đặc điểm thành phần tế bào máu ngoại vi ở bệnh nhân ung thư vú tại Bệnh viện Trung ương Thái Nguyên. J Sci Technol Thai Nguyen Univ. 2022;227(05):245.
11. Krenn-Pilko S, Langsenlehner U, Stojakovic T, et al. An elevated preoperative plasma Fibrinogen level is associated with poor disease-specific and overall survival in breast cancer patients. Breast. 2015; 24(5): 667-672.