MERS Rotavirus-associated mild encephalopathy with a reversible splenial lesion (MERS): A case report
Main Article Content
Abstract
Rotavirus is a common cause of acute gastroenteritis in children. Mild encephalopathy with a reversible splenial lesion (MERS) is a rare neurological complication associated with Rotavirus infection. MERS is a clinico-radiological syndrome characterized by reversible lesions in the splenium of the corpus callosum and complete clinical recovery. We report a case of a 31-month-old female presenting with Rotavirus-induced acute gastroenteritis, accompanied by altered consciousness, seizures, and MRI findings of a splenial lesion. She was diagnosed with MERS associated with Rotavirus infection. The patient experienced full neurological recovery, with resolution of the lesion on follow-up brain MRI. Conclusion: Neurological manifestations in children with Rotavirus gastroenteritis should raise suspicion for potential neurological complications. MERS related to Rotavirus infection is a rare but benign condition with a favorable prognosis, characterized by spontaneous and complete recovery despite the absence of specific treatment.
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Keywords
Rotavirus, Mild encephalopathy with a reversible splenial lesion (MERS), children
References
2. Lee KY. Rotavirus infection-associated central nervous system complications: clinicoradiological features and potential mechanisms. Clinical and experimental pediatrics. Oct 2022;65(10):483-493. doi:10.3345/cep.2021.01333
3. Tada H, Takanashi J, Barkovich AJ, et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology. Nov 23 2004;63(10):1854-8. doi:10.1212/01.wnl.0000144274.12174.cb
4. Karampatsas K, Spyridou C, Morrison IR, et al. Rotavirus-associated mild encephalopathy with a reversible splenial lesion (MERS)-case report and review of the literature. BMC infectious diseases. Oct 24 2015;15:446. doi:10.1186/s12879-015-1192-5
5. Takanashi J, Barkovich AJ, Yamaguchi K, et al. Influenza-associated encephalitis/encephalopathy with a reversible lesion in the splenium of the corpus callosum: a case report and literature review. AJNR American journal of neuroradiology. May 2004;25(5):798-802.
6. Hellysaz A, Hagbom M. Understanding the Central Nervous System Symptoms of Rotavirus: A Qualitative Review. Viruses. Apr 11 2021;13(4)doi:10.3390/v13040658
7. Jing C, Sun L, Wang Z, et al. Reversible splenial lesion syndrome due to oxcarbazepine withdrawal: case report and literature review. The Journal of international medical research. Mar 2018;46(3):1277-1281. doi:10.1177/0300060517736452
8. Fuchigami T, Goto K, Hasegawa M, et al. A 4-year-old girl with clinically mild encephalopathy with a reversible splenial lesion associated with rotavirus infection. Journal of Infection and Chemotherapy. 2013;19(1):149-153. doi:10.1007/s10156-012-0421-8
9. Fukuda S, Kishi K, Yasuda K, et al. Rotavirus-associated encephalopathy with a reversible splenial lesion. Pediatric neurology. Feb 2009;40(2):131-3. doi:10.1016/j.pediatrneurol.2008.10.015
10. Hoshino A, Saitoh M, Oka A, et al. Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes. Brain & development. May 2012;34(5):337-43. doi:10.1016/j.braindev.2011.07.012
11. Blutt SE, Matson DO, Crawford SE, et al. Rotavirus antigenemia in children is associated with viremia. PLoS medicine. Apr 2007;4(4):e121. doi:10.1371/journal.pmed.0040121
12. Maeda M, Tsukahara H, Terada H, et al. Reversible splenial lesion with restricted diffusion in a wide spectrum of diseases and conditions. Journal of neuroradiology = Journal de neuroradiologie. Oct 2006;33(4):229-36. doi:10.1016/s0150-9861(06)77268-6
13. Kazi AZ, Joshi PC, Kelkar AB, et al. MRI evaluation of pathologies affecting the corpus callosum: A pictorial essay. The Indian journal of radiology & imaging. Oct 2013;23(4):321-32. doi:10.4103/0971-3026.125604