Acute encephalitis associated with human Parvovirus B19 in children: A case report
Main Article Content
Abstract
Parvovirus B19 is a virus that exclusively infects humans, with a wide range of clinical manifestations, including erythema infectiosum, transient aplastic crisis and arthritis. Neurological manifestations associated with Parvovirus B19 are uncommon, and acute encephalitis due to Parvovirus B19 is exceedingly rare. Diagnosis of Parvovirus B19 encephalitis is established by detecting B19-DNA or specific anti-B19 IgM antibodies in cerebrospinal fluid (CSF). More than 50% of patients with Parvovirus B19 encephalitis achieve complete recovery. We report a case of a 4-year-old male presenting with fever, slapped cheeks and altered consciousness. The diagnosis of Parvovirus B19 encephalitis was confirmed by the detection of B19-DNA in CSF using polymerase chain reaction (PCR). The patient was treated with Corticosteroid and supportive care, leading to full recovery and resolution of brain lesions on magnetic resonance imaging (MRI).
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Keywords
Encephalitis, Parvovirus B19, children
References
2. Granerod J, Crowcroft NS. The epidemiology of acute encephalitis. Neuropsychol Rehabil. 2007;17(4-5):406-428. doi:10.1080/09602010600989620
3. Glaser CA, Honarmand S, Anderson LJ, et al. Beyond Viruses: Clinical Profiles and Etiologies Associated with Encephalitis.; 2006. http://cid.oxfordjournals.org/
4. Barah F, Whiteside S, Batista S, et al. Neurological aspects of human parvovirus B19 infection: A systematic review. Rev Med Virol. 2014;24(3):154-168. doi:10.1002/rmv.1782
5. Watanabe T. Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children. World J Clin Pediatr. 2015;4(4):126. doi:10.5409/wjcp.v4.i4.126
6. Young NS, Brown KE. Mechanisms of Disease Parvovirus B19.; 2004. www.nejm.org
7. Cossart YE, Cant B, Field AM, et al. Parvovirus-like particles in Human Sera. The Lancet. 1975;305(7898). doi:10.1016/S0140-6736(75)91074-0
8. Azzi A, Morfini M, Mannucci PM. The transfusion-associated transmission of parvovirus B19. Transfus Med Rev. 1999;13(3):194-204. doi:10.1016/S0887-7963 (99)80033-9
9. Zakrzewska K, Arvia R, Bua G, et al. Parvovirus B19: Insights and implication for pathogenesis, prevention and therapy. Aspects of Molecular Medicine. 2023; 1:100007. doi: 10.1016/j.amolm.2023.100007
10. Barah F, Vallely PJ, Cleator GM, et al. Neurological manifestations of human parvovirus B19 infection. Rev Med Virol. 2003;13(3):185-199. doi:10.1002/rmv.388
11. Douvoyiannis M, Litman N, Goldman DL. Neurologic manifestations associated with parvovirus B19 infection. Clinical Infectious Diseases. 2009;48(12):1713-1723. doi:10.1086/599042
12. Barah F, Vallely PJ, Chiswick ML, et al. Association of human parvovirus B19 infection with acute meningoencephalitis. Lancet 2001; 358:729-30.
13. Qiu J, Soderlund-Venermo M, Young NS. Human parvoviruses. Clinical Microbiology Reviews. 2017;30:43-113. https://doi.org/10.1 128/CMR.00040-16.
14. Venkatesan A, Tunkel AR, Bloch KC, et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. Oct 2013;57(8):1114-28. doi:10.1093/cid/cit458