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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3309
Issue
Vol. 191 No. 6 (2025)
Section
Các bài báo
How to Cite
Anh, B. T. V., Thuý, N. T., Tùng, B. T., Khanh, N. V., Huyền, N. T., Khánh, Đỗ T. H., Minh, P. H., Hương, N. T. T., & Thanh, M. P. (2025). Immunostimulatory effects of N-Hexane extract of Siegesbeckia orientalis l. in the experiment. Journal of Medical Research, 191(6), 344-352. https://doi.org/10.52852/tcncyh.v191i6.3309

Immunostimulatory effects of N-Hexane extract of Siegesbeckia orientalis l. in the experiment

Bui Thi Van Anh, Nguyen Thi Thuy, Bui Thanh Tung, Nguyen Van Khanh, Nguyen Thi Huyen, Do Thi Hong Khanh, Phan Hong Minh, Nguyen Thuc Thu Huong, Mai Phuong Thanh

Main Article Content

Abstract

Siegesbeckia orientalis L. is a medicinal plant recognized for its long-established anti-inflammatory, analgesic, and antioxidant properties. In this study, we investigated the immunomodulatory effects of n-hexane extract from S. orientalis on cyclophosphamide (CY)-induced immunosuppression. Swiss mice were divided into five groups: a control group and four groups receiving CY treatment (one control, one reference group with levamisole, and two groups treated with n-hexane extract at 100 or 300 mg/kg; n = 9 per group). Throughout a 7-day treatment period, mice received a single CY injection on day 4 to induce myelosuppression and immunosuppression. The results indicated that in immunosuppressed mice, n-hexane extract treatment significantly mitigated spleen and thymus weight loss, elevated leukocyte counts, and increased serum TNF-α levels, while also improving lymphoid organ atrophy as observed in histological assessments. These findings provide preliminary evidence of the immunostimulatory properties of S. Orientalis extract, highlighting its potential cell-mediated immune responses enhancement.

Article Details

Keywords

Immunostimulatory, n-hexane, cyclophosphamide, Siegesbeckia orientalis, mice

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