Treatment of acute necrotizing pancreatitis in children by combined endoscopic and surgical intervention: A case report and literature review

Nguyen Thi Ngoc Hong, Do Thi Minh Phuong, Vu Hai Yen, Nguyen Loi, Vu Manh Hoan, Cao Viet Tung, Le Dinh Cong, Dang Thuy Ha, Nguyen Thi Viet Ha

Main Article Content

Abstract

Acute necrotizing pancreatitis is an acute pancreatitis with necrosis of the pancreatic parenchyma, release of cytokines, activation of the coagulation process, tissue ischemia that can lead to multiple organs damage leaving local complications (acute peripancreatic collection, pancreatic pseudocyst, acute necrotic collection, walled-off necrosis), vascular occlusion, systemic (infection, multiple organs failure...). Acute necrotizing pancreatitis is very rare in children but the risk of complications and mortality is very high, requiring timely diagnosis and aggressive treatment. We describe a case of a 3-year-old patient diagnosed with necrotizing pancreatitis due to anatomical abnormalities of the pancreatic duct of the dominant Santorini type. The patient with pancreatic pseudocyst complications was successfully treated with a combination of internal medicine, endoscopic intervention and surgery.

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References

1. Morinville VD, Barmada MM, Lowe ME. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas. 2010;39(1):5-8. doi:10.1097/MPA.0b013e3181baac47
2. Tian G, Zhu L, Chen S, et al. Etiology, case fatality, recurrence, and severity in pediatric acute pancreatitis: a meta-analysis of 48 studies. Pediatr Res. 2022;91(1):56-63. doi:10.1038/s41390-021-01454-
3. David C Whitcomb, Mark E Lowe, Pancreatitis: acute and chronic. Pediatric Gastrointestinal Diseases, 2018, p. 4606-4628
4. Lopez MJ. The changing incidence of acute pancreatitis in children: A single-institution perspective. The Journal of Pediatrics. 2002;140(5):622-624. doi:10.1067/mpd.2002.123880
5. DeBanto J, Goday P, Pedroso M, et al. Acute Pancreatitis in Children. American Journal of Gastroenterology. 2002;97(7):1726-1731. doi:10.1111/j.1572-0241.2002.05833.x
6. Park AJ, Latif SU, Ahmad MU, et al. A comparison of presentation and management trends in acute pancreatitis between infants/toddlers and older children. J Pediatr Gastroenterol Nutr. 2010;51(2):167-170. doi:10.1097/MPG.0b013e3181cea545
7. Morinville VD, Husain SZ, Bai H, et al. Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-265. doi:10.1097/MPG.0b013e31824f1516
8. Nydegger A, Heine RG, Ranuh R, et al. Changing incidence of acute pancreatitis: 10-year experience at the Royal Children’s Hospital, Melbourne. J Gastroenterol Hepatol. 2007 Aug;22(8):1313-6. doi: 10.1111/j.1440-1746.2007.04936.x. Epub 2007 Apr 19. PMID: 17489962.
9. Rosenberg A, Steensma EA, Napolitano LM. Necrotizing pancreatitis: new definitions and a new era in surgical management. Surg Infect (Larchmt). 2015;16(1):1-13. doi:10.1089/sur.2014.123
10. Zeng J, Zhang J, Hu Y, et al. Risk factors for the progression from acute recurrent to chronic pancreatitis among children in China. Front Pediatr. 2022;10:908347. doi:10.3389/fped.2022.908347
11. Banks PA, Bollen TL, Dervenis C, et al, Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102-111. doi:10.1136/gutjnl-2012-302779
12. Aljarabah M, Ammori BJ. Laparoscopic and endoscopic approaches for drainage of pancreatic pseudocysts: a systematic review of published series. Surg Endosc. 2007 Nov;21(11):1936-44. doi: 10.1007/s00464-007-9515-2. Epub 2007 Aug 24. PMID: 17717626.
13. Pan G, Wan MH, Xie KL, et al. Classification and Management of Pancreatic Pseudocysts. Medicine (Baltimore). 2015;94(24):e960. doi:10.1097/MD.0000000000000960
14. Rashid MU, Hussain I, Jehanzeb S, et al. Pancreatic necrosis: Complications and changing trend of treatment. World J Gastrointest Surg. 2019 Apr 27;11(4):198-217. doi: 10.4240/wjgs.v11.i4.198. PMID: 31123558; PMCID: PMC6513789
15. Akshintala VS, Saxena P, Zaheer A, et al. A comparative evaluation of outcomes of endoscopic versus percutaneous drainage for symptomatic pancreatic pseudocysts. Gastrointest Endosc. 2014;79(6):921-928; quiz 983.e2, 983.e5. doi:10.1016/j.gie.2013.10.032
16. Tan JH, Chin W, Shaikh AL, et al. Pancreatic pseudocyst: Dilemma of its recent management (Review). Exp Ther Med. 2021 Feb;21(2):159. doi: 10.3892/etm.2020.9590. Epub 2020 Dec 18. PMID: 33456526; PMCID: PMC7792492.
17. Saul A, Ramirez Luna MA, et al. EUS-guided drainage of pancreatic pseudocysts offers similar success and complications compared to surgical treatment but with a lower cost. Surg Endosc. 2016 Apr;30(4):1459-65. doi: 10.1007/s00464-015-4351-2. Epub 2015 Jul 3. PMID: 26139498.