Article Sidebar

PDF (Tiếng Việt)
Published: 2025-08-29
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v193i8.3321
Issue
Vol. 193 No. 8 (2025)
Section
Các bài báo
How to Cite
Lâm, H. K. ., Tuấn, T. A. ., & Dương, N. V. . (2025). Microbial etiology in children with severe persistent/recurrent pneumonia at the National Children’s Hospital. Journal of Medical Research, 193(8), 335-344. https://doi.org/10.52852/tcncyh.v193i8.3321

Microbial etiology in children with severe persistent/recurrent pneumonia at the National Children’s Hospital

Hoang Kim Lam, Ta Anh Tuan, Nguyen Van Duong

Main Article Content

Abstract

The study aims to identify microbiological etiologies in children with severe persistent/recurrent pneumonia (sPP/RP) admitted to the Intensive Care Unit (ICU) of the National Children's Hospital. This is prospective descriptive study on 187 children with sPP/RP admitted to the ICU from November 2019 to October 2020, of whom 93 children had sRP, accounting for 49.7%, 34 children had sPP (18.2%) and 60 children had sPP+RP (32.1%). The results showed that viruses were the leading cause (48.1%), most commonly RSV (24.6%), CMV (15.5%), Rhinovirus (9.6%) and Adenovirus (7%). Bacteria accounted for 32.6%, in children of severe recurrent pneumonia (sRP), the prominent pathogens were the cause of community-acquired pneumonia: Haemophilus influenzae (33.3%), Streptococcus pneumonia (16.7%), Staphylococcus aureus (16.7%). In the severe persistent pneumonia group (sPP and sPP+RP), the main pathogens detected were Staphylococcus aureus (47.1% in the sPP group; 25% in the sPP+RP group) and gram-negative causing ventilator-associated pneumonia: Klebsiella pneumonia (17.7% in the sPP group; 15% in the sPP+RP group), Acinetobacter baumannii (11.8% in the sPP group; 25% in the sPP+RP group), Pseudomonas aeruginosa (5.9% in the sPP group, 10% in the sPP+RP group). Additionally, 5.3% had PCP, while tuberculosis and other fungi were found at low rates (2.7% and 3.2%, respectively).

Article Details

Keywords

Severe pneumonia, persistent pneumonia, recurrent pneumonia, microbial etiology, microorganisms

References

1. Bolursaz MR, Lotfian F, Ghaffaripour HA, et al. Underlying causes of persistent and recurrent pneumonia in children at a Pulmonary Referral Hospital in Tehran, Iran. Archives of Iranian Medcine. 2017;20(5):266-269.
2. Saad K, Mohamed SA, Metwalley KA. Recurrent/Persistent Pneumonia among Children in Upper Egypt. Mediterranean Journal of Hematology and Infectious Diseases. 2013;5(1):e2013028.
3. Lodha R, SK Kabra. Persistent pneumonia in children. Indian Pediatrics. 2003;40(10):967-970.
4. Kumar M, Biswal N, Bhuvaneswari1 V, et al. Persistent pneumonia: underlying cause and outcomes. Indian Journal of Pediatrics. 2009;76(12):1223-1226.
5. Koh JWJC, Wong JJM, Sultana R, et al. Risk factors for mortality in children with pneumonia admitted to the pediatric intensive care unit. Pediatric pulmonology. 2017;52(8):1076-1084.
6. WHO. Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. World Health Organization. 2001.
7. Todd A Florin, Cole Brokamp, Rachel Mantyla, et al. Validation of the PIDS/IDSA severity criteria in children with community-acquired pneumonia. Clinical Infectious Diseases. 2018;67(1):112-9.
8. Phạm Ngọc Toàn. Căn nguyên vi sinh vật của bệnh viêm phổi tái nhiễm ở trẻ em tại Bệnh viện Nhi Trung ương năm 2016 - 2018. Tạp chí Y học Việt Nam. 2020;497(2):91-94.
9. Phạm Thị Thanh Tâm, Lê Ngọc Duy, Phùng Thị Bích Thủy, và cs. Nhận xét đặc điểm bệnh lý nền ở trẻ viêm phổi tái diễn có suy hô hấp tại Bệnh viện Nhi Trung ương. Tạp chí Y học Việt Nam. 2020;494(2):181-184.
10. Tural-Kara T, Özdemir H, Yıldız N, et al. Underlying diseases and causative microorganisms of recurrent pneumonia in children: a 13-year study in a university hospital. Journal of Tropical Pediatrics. 2018;65(3):224-230.
11. Phạm Thu Nga, Nguyễn Thị Yến, và cs. Căn nguyên vi sinh và bệnh lý nền liên quan tới viêm phổi kéo dài ở trẻ từ 2 tháng – 5 tuổi tại Trung tâm Hô hấp, Bệnh viện Nhi Trung ương. Tạp chí Y học Việt Nam. 2020;494(2):146-149.
12. Chen L-L, Liu Y-C, Lin H-C, et al. Clinical characteristics of recurrent pneumonia in children with or without underlying diseases. Journal of the Formosan Medical Association. 2022; 121(6):1073-1080.
13. Lê Xuân Ngọc. Đặc điểm dịch tễ học viêm phổi liên quan thở máy ở trẻ ngoài tuổi sơ sinh tại khoa Hồi sức - Cấp cứu, Bệnh viện Nhi Trung ương. Luận án Tiến sĩ Y học, viện Vệ sinh dịch tễ Trung ương. 2017.
14. Nguyễn Thị Lệ Thúy, Hoàng Trọng Kim. Đánh giá viêm phổi ở trẻ được thông khí hỗ trợ tại khoa Hồi sức cấp cứu, Bệnh viện Nhi đồng 1. Tạp chí Y học TP Hồ Chí Minh. 2005;9(phụ bản của Số 1):1-6.
15. Venkatachalam V, Hendley JO, Willson DF. The diagnostic dilemma of ventilator-associated pneumonia in critically ill children. Pediatric Critical Care Medicine. 2011;12(3):286-296.
16. De Schutter I, De Wachter E, Crokaert F, et al. Microbiology of bronchoalveolar lavage fluid in children with acute nonresponding or recurrent community-acquired pneumonia: identification of nontypeable Haemophilus influenzae as a major pathogen. Clinical Infectious Diseases. 2011;52(12):1437-1444.