Effect of “thuoc vien khop Abipha” on monosodium iodoacetate - induced osteoarthritis in rats
Main Article Content
Abstract
“Thuoc vien khop Abipha” contains various medicinal herbs demonstrating anti-inflammatory and pain-relieving properties while inhibiting cartilage degradation. The study was performed on albino Wistar rats using a knee osteoarthritis model induced by MIA (monosodium-iodoacetate) at 3 mg/joint to assess the anti-osteoarthritis effects of the formulation in experiments. The medications evaluated included diclofenac at 3 mg/kg and “Thuoc vien khop Abipha” at 216 mg/kg and 648 mg/kg. After 6 weeks of continuous administration, both diclofenac at 3 mg/kg and “Thuoc vien khop Abipha” at 216 mg/kg and 648 mg/kg exhibited anti-osteoarthritis effects in rats by alleviating knee pain, inhibiting cartilage degradation, and reducing cytokine levels (IL-1β, TNF-α).
Article Details
Keywords
Wistar rats, knee osteoarthritis, MIA, monosodium-iodoacetate, Abipha
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