Nghiên cứu độc tính cấp, bán trường diễn của Thống Phong hoàn Bà Giằng trên thực nghiệm

Abstract

Thong Phong hoan Ba ​​Giang is a herbal combination with the intended purpose of preventing and treating acute and chronic gout. This study aimed to evaluate the acute and subchronic toxicity of Thong Phong hoan Ba ​​Giang in experimental animals. The acute toxicity was evaluated in Swiss mice by administering the increasing doses to determine the lowest dose that would induce 100% mouse mortality and the highest dose corresponding to 0% mouse mortality. The subchronic toxicity was evaluated in Wistar rats at 4.32 tablets (equivalent to the clinical dose) and 12.96 tablets/kg b.w/day (three times higher than the clinical dose) for 90 consecutive days. Our results showed that Thong Phong hoan Ba ​​Giang at the dose up to 150 tablets/kg b.w did not cause mortality or any abnormal signs in Swiss mice; at the doses of 4.32 tablets and 12.96 tablets/kg b.w did not significantly affect the general condition, body weight, hematological and biochemical indices and microscopic morphology of liver and kidney of Wistar rats. In conclusion, Thong Phong hoan Ba ​​Giang did not cause acute and subchronic toxicity when administered orally to animals at the tested doses.