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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3360
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Vol. 191 No. 6 (2025)
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Các bài báo
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Hằng, N. T. T., Bình, N. T. T., Hương, N. T. T., Thuý, N. T., Minh, P. H., Mai, N. T., Trang, H. T., Thanh, M. P., Hà, N. T. T., & Khánh, Đỗ T. H. (2025). Study of acute, sub-chronic toxicity and anti-hyperuricemic activity of n-hexane fraction of Kaempferia galanga l. on experimental animals . Journal of Medical Research, 191(6), 374-385. https://doi.org/10.52852/tcncyh.v191i6.3360

Study of acute, sub-chronic toxicity and anti-hyperuricemic activity of n-hexane fraction of Kaempferia galanga l. on experimental animals

Nguyen Thi Thuý Hang, Nguyen Thi Thanh Binh, Nguyen Thuc Thu Huong, Nguyen Thi Thuy, Phan Hong Minh, Nguyen Thi Mai, Hoang Thu Trang, Mai Phuong Thanh, Nguyen Thi Thanh Ha, Do Thi Hong Khanh

Main Article Content

Abstract

The study evaluates the acute, sub-chronic toxicity and anti-hyperuricemic activity of n-hexane fraction of Kaempferia galanga L. on experimental models. Acute toxicity was assessed using the Litchfield-Wilcoxon method on Swiss albino mice. The sub-chronic toxicity was evaluated following WHO guidelines on Wistar rats at the daily doses of 50 mg/kg/day and 150 mg/kg/day for 4 weeks. The anti-hyperuricemic effect was tested at doses of 100 mg/kg/day and 300 mg/kg/day on Swiss mice, which were intraperitoneally injected with a single dose of potassium oxonate suspension (500 mg/kg). The results showed that n-hexane fraction exhibited acute oral toxicity with an LD50 of 3671.94 mg/kg. In the sub-chronic toxicity study, both dose levels caused no change in general health status, body weight, hematopoietic function, liver and kidney function, or renal structure. However, histopathological changes in the liver were observed at the higher dose, warranting further investigation. Both dose levels demonstrated a blood uric acid-lowering effect.

Article Details

Keywords

Acute toxicity, subchronic toxicity, uric acid, n-hexane, Kaempferia galanga

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