Đặc điểm phân bố, mức độ kháng kháng sinh của Klebsiella pneumoniae tại Bệnh viện Trung ương Quân đội 108 (tháng 2 -4/2024)

Abstract

Klebsiella pneumoniae is a common cause of infections in hospitals and communities, ranging from mild to severe. Currently, K. pneumoniae is becoming a public health concern due to its pathogenicity and resistance to many antibiotics, posing a significant challenge in clinical treatment and disease prevention. A cross-sectional descriptive study was conducted on 163 Klebsiella pneumoniae isolates obtained from clinical specimens of patients at the 108 Military Central Hospital. The objective of the study was to describe the distribution characteristics and antibiotic resistance patterns of Klebsiella pneumoniae isolated at the 108 Military Central Hospital from February to April 2024. The results showed that K. pneumoniae was mainly isolated from male patients (74.2%), over 60 years old (70%) and treated in internal medicine (81%). The bacteria were isolated from many different specimens, the most common of which was respiratory tract secretions. The results of the antibiotic susceptibility test showed that K. pneumoniae was more than 50% resistant to 13/14 tested antibiotics, of which the resistance rate to the aminoglycoside group was the lowest (amikacin: 39.5%; gentamicin 48.1%). There were 77 carbapenem-resistant strains (accounting for 47.2%) with minimum inhibitory concentration (MIC) values ​​determined with two antibiotics, ceftazidime/avibactam and colistin. With a threshold value of MIC ≥ 4 µg/ml, K. pneumoniae strains had a resistance rate of colistin of 14.3%. Meanwhile, only 31.2% of strains had MIC with ceftazidime/avibactam ≤ 8 µg/ml, reaching the sensitivity level according to CLSI 2023 classification.