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Published: 2025-08-29
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DOI: https://doi.org/10.52852/tcncyh.v193i8.3384
Issue
Vol. 193 No. 8 (2025)
Section
Các bài báo
How to Cite
Thanh, Đỗ C. ., Lê, N. Đinh ., Trang, H. T. ., Nam, T. H. ., Linh, H. T. T. ., Nhung, N. T. T. ., Bình, N. T. ., & Dung, L. T. T. . (2025). Treatment outcomes of central nervous system germ cell tumors at the Pediatrics Department of Vietnam National Cancer Hospital. Journal of Medical Research, 193(8), 251-259. https://doi.org/10.52852/tcncyh.v193i8.3384

Treatment outcomes of central nervous system germ cell tumors at the Pediatrics Department of Vietnam National Cancer Hospital

Do Cam Thanh, Nguyen Dinh Le, Hoang Thu Trang, Tran Hai Nam, Hoang Thi Thuy Linh, Nguyen Thi Thu Nhung , Nguyen Thi Binh, Le Thi Thuy Dung

Main Article Content

Abstract

We retrospectively evaluated outcomes of central nervous system germ cell tumor patients (CNS GCTs) treated at the Pediatric Department of K hospital from 2017 to 2021. 44 patients were classified as low risk (LR) or high risk (HR) based on pathologic diagnosis and tumor markers. The median age at diagnosis was 13 years old (range, 11.1 - 15), 79.5% were males and 77.3% of patients were LR. The most frequent tumor location was pineal gland (29,5%) and sellar/suprasellar (29.5%). The 5-years overall survival and event free survival rates were 81.8% và 77.5%, respectively. The 5-year OS of the LR was higher than the HR groups (88.2% and 60%; p = 0.037) but there was no significant difference in the 5-year EFS between 2 groups (LR 82.4% vs 60%; p = 0.074). Most of mortalities were related to disease progression. Conclusion: The strategy of treating CNS GCTs with chemotherapy and radiation therapy according to risk groups resulted in good clinical outcomes. However, further research is needed to monitor the long-term complications.

Article Details

Keywords

Germ cell tumor, Non-germinoma, Central nervous system germ cell tumor, germinoma, K hospital

References

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