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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3390
Issue
Vol. 191 No. 6 (2025)
Section
Các bài báo
How to Cite
Quyên, N. T. P., Hà, N. H., Phen, P. V., Thủy, M. L., & Hoà, T. (2025). Prediction of cardiovascular events in chronic heart failure patients based on ngal and NT-proBNP values. Journal of Medical Research, 191(6), 122-130. https://doi.org/10.52852/tcncyh.v191i6.3390

Prediction of cardiovascular events in chronic heart failure patients based on ngal and NT-proBNP values

Nguyen Thi Phuong Quyen, Nguyen Hong Ha, Phan Van Phen, Mai Long Thuy, Tran Hoa

Main Article Content

Abstract

NGAL and NT-proBNP levels have shown potential in predicting cardiovascular events in patients with acute decompensation of chronic heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate the characteristics and predictive value of NGAL and NT-proBNP concentrations for cardiovascular events in patients with acute decompensated HFrEF. A cross-sectional descriptive study was conducted on 73 patients with acute HFrEF at Can Tho Central General Hospital from June 2024 to February 2025. Results: Male patients accounted for 60.3% of the study population. 30.1% of patients experienced cardiovascular events, including rehospitalization for heart failure: 24.7%, acute myocardial infarction: 9.6%, cardiovascular death: 11.0%. In predicting cardiovascular events, NGAL had an AUC of 0.91 at the cut-off value of 82.2 ng/mL, sensitivity was 86.4%, and specificity was 98.0%. NT-proBNP at a cut-off value of 2043.0 pg/mL had an AUC of 0.86, with 95.5% sensitivity and 68.6% specificity. Conclusion: These results suggest that NGAL and NT-proBNP are highly valuable biomarkers in predicting cardiovascular events in patients with acute decompensated chronic heart failure with reduced ejection fraction.

Article Details

Keywords

Acute, chronic heart failure, NGAL levels, cardiovascular events

References

1. Paul A Heidenreich, Biykem Bozkurt, David Aguilar, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2022; 79(17): p. e263-e421. doi: 10.1161/CIR.0000000000001063.
2. Theresa A McDonagh, Marco Metra, Marianna Adamo, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology With the special contribution of the Heart Failure Association of the ESC. European heart journal. 2021; 42(36): p. 3599-3726. doi: 10.1093/eurheartj/ehab368.
3. Amar M Salam, Kadhim Sulaiman, Alawi A Alsheikh-Ali, et al. Precipitating factors for hospitalization with heart failure: prevalence and clinical impact observations from the Gulf CARE (Gulf acute heart failure registry). Medical Principles and Practice. 2020; 29(3): p. 270-278. doi: 10.1159/000503334.
4. Arjun K Gupta, Daniela Tomasoni, Kiran Sidhu, et al. Evidence-based management of acute heart failure. Canadian Journal of Cardiology. 2021; 37(4): p. 621-631. doi: 10.1016/j.cjca.2021.01.002.
5. Alberto Aimo, James L Januzzi Jr, Christian Mueller, et al. Admission high-sensitivity troponin T and NT-proBNP for outcome prediction in acute heart failure. International journal of cardiology. 2019; 293(1): p. 137-142. doi: 10.1016/j.ijcard.2019.06.005.
6. Rocio Blanco, Giuseppe Ambrosio, Cesar Belziti, et al. Prognostic value of NT-proBNP, and echocardiographic indices of diastolic function, in hospitalized patients with acute heart failure and preserved left ventricular ejection fraction. International Journal of Cardiology. 2020. 317(1): p. 111-120, doi: 10.1016/j.ijcard.2020.04.044.
7. Alan S Maisel, Christian Mueller, Robert Fitzgerald, et al. Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. European journal of heart failure. 2011; 13(8): p. 846-851. doi: 10.1093/eurjhf/hfr087.
8. Trần Tố Nguyệt. Nghiên cứu giá trị và khả năng dự báo biến cố suy tim của nồng độ NGAL và NT-proBNP huyết thanh ở bệnh nhân hội chứng vành cấp tại Bệnh viện Trường Đại học Y Dược Cần Thơ. Tạp chí Y Dược học Cần Thơ. 2022. Số 47. tr. 39-46.
9. Mattia Arrigo, Mariell Jessup, Wilfried Mullens, et al. Acute heart failure. Nature Reviews Disease Primers. 2020. 6(1): p. 16. doi: 10.1038/s41572-020-0151-7.
10. Alain Rudiger, Veli-Pekka Harjola, Andreas Müller, et al. Acute heart failure: clinical presentation, one-year mortality and prognostic factors. European journal of heart failure. 2005. 7(4): p. 662-670. doi: 10.1016/j.ejheart.2005.01.014.
11. Carlo Lombardi, Giulia Peveri, Dario Cani, et al. In-hospital and long-term mortality for acute heart failure: analysis at the time of admission to the emergency department. ESC Heart Failure. 2020. 7(5): p. 2650-2661. doi: 10.1002/ehf2.12847.
12. Javier A Neyra, Ming-Chang Hu, Abu Minhajuddin, et al. Kidney tubular damage and functional biomarkers in acute kidney injury following cardiac surgery. Kidney international reports. 2019: p. 1131-1142. doi: 10.1016/j.ekir.2019.05.005.
13. Arrigo M, et al. Understanding acute heart failure: pathophysiology and diagnosis. European Heart Journal. 2016. 18(1): p. G11-G18. doi :10.1093/eurheartj/suw044.
14. Rani Paramitha Iswari Maliawan, et al. Serum neutrophil gelatinase-associated lipocalin and decreased kidney function as predictor of mortality and major adverse cardiac events during acute heart failure hospitalizations. Bali Medical Journal. 2021. 10(2): p. 857-862. doi: 10.15562/bmj.v10i2.2541.
15. Tran Viet An, et al. Mortality prognosis of NGAL, NTproBNP, hsTnT, and GRACE score in patients with acute coronary syndrome. IJC Heart & Vasculature. 2024. 50: p. 101338.