Efficacy of probiotics regimens in Helicobacter pylori eradication in pediatric gastroduodenal ulcers: A systematic review
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Abstract
This study systematically reviewed the efficacy of probiotics as an adjunct in Helicobacter pylori (H. pylori) eradication therapy in children with gastroduodenal ulcers. Data from 13 randomized controlled trials (2005-2017) involving 1374 children were analyzed. Probiotics increased H. pylori eradication rates by 14% (RR = 1.14; 95% CI: 1.03 - 1.26). Supgroup analysis showed that the Lactobacillus strains and multi-strain combinations particularly increased the eradication rate by 19% and 14%, respectively. Probiotic supplementation reduced the adverse effects of H. pylori eradication therapy up to 60% (RR = 0.40; 95% CI: 0.26 - 0.62), with a notable 66% reduction of diarrhea (RR = 0.34; 95% CI: 0.19 - 0.60). No adverse effect related to probiotic supplementation was reported. As shown, probiotics enhance eradication and tolerability, offering a promising adjunctive approach in pediatric H. pylori management.
Article Details
Keywords
Probiotics, Helicobacter pylori, pediatric gastroduodenal ulcers, systematic review
References
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