Hiệu quả của hai phác đồ sử dụng polyethylene glycol 3350 và lactulose trong điều trị táo bón mạn tính chức năng ở trẻ em dưới 6 tuổi

Abstract

Constipation is a common childhood gastrointestinal disease. This study aimed to evaluate the efficacy of polyethylene glycol 3350 and lactulose for the treatment of chronic functional constipation in children younger than six years old. An open, randomized, controlled clinical trial was done in chronic funtional constipated children (12 to 72 months) according to ROME IV criteria. 156 children were randomized to 2 groups to receive either lactulose (1.5ml/kg/day) or polyethylene glycol 3350 (0.5g/kg/day) regimen for 3 months. Results showed that the average number of defecation per week and the rate of soft stools in both groups increased significantly at 1, 2, 3 months after treatment (p < 0.001). The percentage of children who improved the average number of defecation per week, soft stools without blood, defecation pain, defecation exertion and fecal retentive posturing in the group using polyethylene glycol 3350 was higher than in the group using lactulose at the times of evaluation (p < 0.05). The rate of side effects of the polyethylene glycol 3350 group was significantly lower than the lactulose ones, p < 0.05. The effectiveness of treatment increased gradually from 81.8% after 1 month of treatment to 93.9% and 95.4% after 2 and 3 months among group using the polyethylene glycol 3350. Effectiveness of the polyethylene glycol 3350 regimen was significantly higher than the lactulose regimen at the times of evaluation, p < 0.05. Polyethylene glycol 3350 has more effectiveness and less side effects than lactulose in treatment of chronic functional constipation in children less than six years old.