4. Prognostic value of PET/CT for overall survival in patients with hypopharyngeal cancer undergoing concurrent chemoradiotherapy at National Cancer Hospital
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Abstract
Hypopharyngeal cancer is a common malignant disease among head and neck cancers. This restrospective cross-sectional study included 67 patients with hypopharyngeal cancer who underwent concurrent chemoradiotherapy from January 2019 to January 2024 at K Hospital. The objective of the study was to evaluate the prognostic value of pre-treatment PET/CT imaging parameters, specifically SUVmax and metabolic tumor volume (MTV), for overall survival in patients receiving concurrent chemoradiotherapy. The findings demonstrated that SUVmax ≥ 15.5 or MTV ≥ 11cm³ were independent prognostic factors for overall survival, regardless of tumor stage or location, with corresponding hazard ratios (HRs) of 3,21 (p = 0.003) and 2.02 (p = 0.025), respectively.
Article Details
Keywords
Hypopharyngeal cancer, concurrent chemoradiotherapy, PET/CT, overall survival
References
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2. Garneau JC, Bakst RL, Miles BA. Hypopharyngeal cancer: A state of the art review. Oral Oncology. 2018; 86: 244-250. doi:10.1016/j.oraloncology.2018.09.025.
3. Roh JL, Pae KH, Choi SH, et al. 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol. 2007; 33(6): 790-795. doi:10.1016/j.ejso.2007.01.002.
4. Lee MS, Ho HC, Hsiao SH, Hwang JH, Lee CC, Hung SK. Treatment results and prognostic factors in locally advanced hypopharyngeal cancer. Acta Otolaryngol. 2008; 128(1): 103-109. doi:10.1080/00016480701387116.
5. Al-Ibraheem A, Buck A, Krause BJ, Scheidhauer K, Schwaiger M. Clinical Applications of FDG PET and PET/CT in Head and Neck Cancer. Journal of Oncology. 2009; 2009(1): 208725. doi:10.1155/2009/208725.
6. Suzuki H, Kato K, Fujimoto Y, et al. 18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma. Ann Nucl Med. 2013; 27(3): 297-302. doi:10.1007/s12149-013-0686-8.
7. Werner J, Hüllner MW, Rupp NJ, et al. Predictive Value of Pretherapeutic Maximum Standardized Uptake Value (Suvmax) In Laryngeal and Hypopharyngeal Cancer. Sci Rep. 2019; 9: 8972. doi:10.1038/s41598-019-45462-y.
8. Suzuki S, Toyoma S, Abe T, et al. 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma. Journal of Otolaryngology - Head & Neck Surgery. 2022; 51(1): 13. doi:10.1186/s40463-022-00568-8.
9. Koyasu S, Nakamoto Y, Kikuchi M, et al. Prognostic value of pretreatment 18F-FDG PET/CT parameters including visual evaluation in patients with head and neck squamous cell carcinoma. AJR Am J Roentgenol. 2014; 202(4): 851-858. doi:10.2214/AJR.13.11013.
10. Suzuki H, Nishio M, Nakanishi H, et al. Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncol Lett. 2016; 12(2): 1493-1500. doi:10.3892/ol.2016.4765.
11. Huang C, Zhang L, Meng Z, et al. Prognostic Value of 18F-Fluorodeoxyglucose–Positron Emission Tomography/Magnetic Resonance Imaging in Patients With Hypopharyngeal Squamous Cell Carcinoma. Journal of Computer Assisted Tomography. 2022; 46(6): 968. doi:10.1097/RCT.0000000000001365.
12. Nguyễn Đình Phúc. Nghiên cứu đặc điểm lâm sàng, đối chiếu chụp cắt lớp vi tính của ung thư hạ họng. Tạp chí Y học Việt Nam. October 2023: 65-68.
13. Paximadis P, Yoo G, Lin HS, et al. Concurrent Chemoradiotherapy Improves Survival in Patients With Hypopharyngeal Cancer. Int J Radiat Oncol Biol Phys. 2012; 82(4): 10.1016/j.ijrobp.2011.04.064. doi:10.1016/j.ijrobp.2011.04.064.
14. Ng SH, Liao CT, Lin CY, et al. Dynamic contrast-enhanced MRI, diffusion-weighted MRI and 18F-FDG PET/CT for the prediction of survival in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiation. Eur Radiol. 2016; 26(11): 4162-4172. doi:10.1007/s00330-016-4276-8.
15. Park GC, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY. Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx. Ann Oncol. 2013; 24(1): 208-214. doi:10.1093/annonc/mds247.
16. Hanamoto A, Tatsumi M, Takenaka Y, et al. Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy. Cancer Med. 2014; 3(5): 1368-1376. doi:10.1002/cam4.295.
17. Bosch S van den, Doornaert PAH, Dijkema T, et al. 18F-FDG-PET/CT-based treatment planning for definitive (chemo)radiotherapy in patients with head and neck squamous cell carcinoma improves regional control and survival. Radiotherapy and Oncology. 2020;142:107-114. doi:10.1016/j.radonc.2019.07.025
18. Eckel HE, Bradley PJ. Treatment Options for Hypopharyngeal Cancer. Adv Otorhinolaryngol. 2019; 83: 47-53. doi:10.1159/000492308.