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Published: 2025-08-29
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DOI: https://doi.org/10.52852/tcncyh.v193i8.3570
Issue
Vol. 193 No. 8 (2025)
Section
Các bài báo
How to Cite
Thảo, L. H. ., An, Đào N. ., Thanh, M. P. ., & Vân Anh, P. T. . (2025). Anti-inflammatory and antipruritic effects of the polyherbal formulation TAD. Journal of Medical Research, 193(8), 441-449. https://doi.org/10.52852/tcncyh.v193i8.3570

Anti-inflammatory and antipruritic effects of the polyherbal formulation TAD

Le Hai Thao, Dao Ngoc An, Mai Phuong Thanh, Pham Thi Van Anh

Main Article Content

Abstract

The polyherbal formulation TAD is a formulation composed of 7 medicinal herbs extraction including: Cortex Phellodendri, Rhizoma Rhei, Caulis et Radix Fibraureae, Fructus Xanthii strumarii, Folium et Ramulus Crotonis tonkinensis, Folium Lawsoniae. The topical anti-inflammatory and antipruritic activities of TAD extract were evaluated in Swiss mice. The topical anti-inflammatory effects were studied in the croton oil-induced ear edema. The anti-puritic activities of the extract was tested using the compound 48/80-induced pseudo-allergy model. Topical application of TAD twice or three times daily inhibited ear edema by 32.98% and 33.98%, respectively. Furthermore, the administration of TAD trendly inhibited the scratching behavior induced by compound 48/80 in mice. These results suggested that TAD extract has potential as a therapeutic agent against inflammation and itch-related skin diseases.

Article Details

Keywords

TAD, herbal preparation, croton oil, compound 48/80, mice

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