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Published: 2025-06-16
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DOI: https://doi.org/10.52852/tcncyh.v191i6.3579
Issue
Vol. 191 No. 6 (2025)
Section
Các bài báo
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Xoay, T. Đăng, My, T. T. K., Kiên, N. T., Trang, N. T., Duyên, N. T., & Tuấn, T. A. (2025). Diagnostic value of multiple organ dysfunction syndrome and mortality of fibrin monomer in children with sepsis. Journal of Medical Research, 191(6), 296-302. https://doi.org/10.52852/tcncyh.v191i6.3579

Diagnostic value of multiple organ dysfunction syndrome and mortality of fibrin monomer in children with sepsis

Tran Dang Xoay, Tran Thi Kieu My, Nguyen Tat Kien, Nguyen Thi Trang, Nguyen Thi Duyen, Ta Anh Tuan

Main Article Content

Abstract

Sepsis is a leading cause of morbidity and mortality in children. Sepsis-induced coagulations is a predictor of mortality. Coagulation disorders in patients with sepsis can lead to multiple organ dysfunction syndrome (MODS), and associated with death. Fibrin monomer (FM) is generated from the degradation of fibrinogen by thrombin. We hypothesize that FM levels are elevated in pediatric patients with sepsis and MODS. We measured FM levels in 139 pediatric patients with sepsis at the Vietnam National Children’s Hospital between June 2021 and October 2024. Method: This was a cohort study to access the prognostic value of FM in pediatric sepsis. Main results: FM levels in pediatric sepsis showed a favorably correlation with the number of dysfunctional organs. The performance of prognostic value of MODS of FM is “fair”, while the performance of prognostic value of mortality of FM is “poor” in pediatric sepsis.

Article Details

Keywords

Pediatric, sepsis, fibrin monomer, DIC, MODS

References

1. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet. 2020; 395(10219): 200-211. doi:10.1016/S0140-6736(19)32989-7.
2. Levi M, De Jonge E, Van der Poll T, Vincent JL, Ficher C, Reinhart K. Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation. Crit Care Med. 2001; 29(7 Suppl). doi:10.1097/00003246-200107001-00028.
3. Tuan TA, Ha NTT, Xoay TD, My TTK. Fibrinolytic Impairment and Mortality in Pediatric Septic Shock: A Single-Center Prospective Observational Study. Pediatric Critical Care Medicine. 2021; 22(11):969-977. doi:10.1097/PCC.0000000000002759.
4. Tuan TA, Ha NTT, Xoay TD, My TTK, Nghiem LT, Dien TM. Hypocoagulable Tendency on Thromboelastometry Associated With Severity and Anticoagulation Timing in Pediatric Septic Shock: A Prospective Observational Study. Front Pediatr. 2021; 9. doi:10.3389/fped.2021.676565.
5. Park KJ, Kwon EH, Kim HJ, Kim SH. Evaluation of the Diagnostic Performance of Fibrin Monomer in Disseminated Intravascular Coagulation. Korean J Lab Med. 2011; 31(3): 143. doi:10.3343/KJLM.2011.31.3.143.
6. Wada H, Gabazza EC, Asakura H, et al. Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for overt DIC. undefined. 2003; 74(1): 17-22. doi:10.1002/AJH.10377.
7. Bembea MM, Agus M, Akcan-Arikan A, et al. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022; 149(1 Suppl 1). doi:10.1542/PEDS.2021-052888B.
8. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005; 6(1). doi:10.1097/01.PCC.0000149131.72248.E6.
9. Schlapbach LJ, Watson RS, Sorce LR, et al. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. Published online January 21, 2024. doi:10.1001/JAMA.2024.0179.
10. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996; 24(5): 743-752. doi:10.1097/00003246-199605000-00004.
11. Tuan TA, Xoay TD, My TTK, et al. Reference Value Fibrin Monomer in Healthy Children: A Cross-Sectional Study. Clin Appl Thromb Hemost. 2024; 30. doi:10.1177/10760296241247560.
12. Bui-Thi HD, To Gia K, Le Minh K. Coagulation profiles in patients with sepsis/septic shock identify mixed hypo-hypercoagulation patterns based on rotational thromboelastometry: A prospective observational study. Thromb Res. 2023; 227: 51-59. doi:10.1016/j.thromres.2023.05.010.
13. Levi M. Inflammation and Coagulation. Inflammation - From Molecular and Cellular Mechanisms to the Clinic. Published online October 31, 2017: 833-860. doi:10.1002/9783527692156.CH32.
14. Wada H, Kobayashi T, Abe Y, et al. Elevated levels of soluble fibrin or D-dimer indicate high risk of thrombosis. J Thromb Haemost. 2006; 4(6): 1253-1258. doi:10.1111/J.1538-7836.2006.01942.X.
15. Ikeda N, Wada H, Ichikawa Y, et al. D-dimer kit with a High FDP/D-Dimer Ratio is Useful for Diagnosing Thrombotic Diseases. Clin Appl Thromb Hemost. 2022; 28. doi:10.1177/10760296211070584.