49. Effect of “Khoi tim Bavieco” capsules on experimental gastroesophageal reflux model
Main Article Content
Abstract
Gastroesophageal reflux (GERD) is one of the most common diseases of the digestive system. This study was conducted to evaluate the effect of Khoi tim Bavieco capsules on the model of GERD-induced esophageal damage in Wistar rats. Rats were divided into five groups: the control group and model group were given orally distilled water, the treated groups were given orally esomeprazole 10 mg/kg b.w/day, Khoi tim Bavieco capsules at 0.48 tablets/kg b.w/day and 1.44 tablets/kg b.w/dayfor seven consecutive days. GERD was induced in rats of groups 2 - 5 by surgery combined with an oral administration of indomethacin. The indices of gastric juice, esophagus, and antioxidant activity were evaluated. Research results showed that Khoi tim Bavieco capsules reduced the gastric juice’s free acidity, reduced the area and extent of esophageal damage; improved microscopic esophageal damage and epithelial thickness, and improved the antioxidant index. In conclusion, Khoi tim Bavieco capsules have the effect of ameliorating GERD-induced esophageal damage in rats.
Article Details
Keywords
Gastroesophageal reflux, Khoi tim Bavieco capsules, Wistar rats, antioxidant
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