14. Association Between Serum 25-Hydroxyvitamin D Levels and the Severity of Dengue Hemorrhagic Fever in Children
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Abstract
Vitamin D is believed to modulate immune responses and may influence the progression of Dengue fever. This cross-sectional study evaluated the association between serum 25-hydroxyvitamin D [25(OH)D] levels and disease severity in 92 pediatric patients diagnosed with Dengue at Can Tho Children’s Hospital. Median 25(OH)D levels tended to decrease with increasing disease severity (Dengue without warning signs: 54.3 ng/mL; with warning signs: 61.9 ng/mL; severe Dengue: 41.8 ng/mL; p = 0.04). Laboratory findings showed that albumin, platelet count, and fibrinogen levels decreased, while hematocrit, liver enzymes, and aPTT increased with disease severity. However, 25(OH)D did not remain statistically significant in the multinomial logistic regression model, suggesting that it may not serve as an independent prognostic factor. These results imply a potential association between vitamin D status and severe forms of Dengue, although further research is needed to elucidate this relationship and explore its possible clinical applications.
Article Details
Keywords
25(OH)D, Vitamin D, Dengue hemorrhagic fever, prognosis, disease severity
References
2. Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature. 2013; 496(7446): 504-507. doi:10.1038/nature12060.
3. Iqtadar S, Khan A, Mumtaz SU, et al. Vitamin D Deficiency (VDD) and Susceptibility towards Severe Dengue Fever-A Prospective Cross-Sectional Study of Hospitalized Dengue Fever Patients from Lahore, Pakistan. Trop Med Infect Dis. 2023; 8(1): 43. doi:10.3390/tropicalmed8010043.
4. Sadarangani SP, Htun HL, Ling W, et al. Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study at a large institution in Singapore. Singapore Med J. 2022; 65(6): 332-339. doi:10.11622/smedj.2022064.
5. Chakravarti A, Bharara T, Kapoor N, Ashraf A. Levels of 25-hydroxy Vitamin D3 and Vitamin D Receptor Polymorphism in Severe Dengue Cases from New Delhi. Trop Med Infect Dis. 2020; 5(2): 72. doi:10.3390/tropicalmed5020072.
6. Villamor E, Villar LA, Lozano A, Herrera VM, Herrán OF. Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. Epidemiol Infect. 2017; 145(14): 2961-2970. doi:10.1017/S0950268817002059.
7. Phuong Minh Nguyen, Linh Van Pham, Kien Trung Nguyen, et al. Vitamin D and bone mineral density status, and their correlation with bone turnover markers in healthy children aged 6-14 in Vietnam. Curr Pediatr Res. 24(3): 203-208.
8. Hoàng Văn Minh, Khương Huỳnh Long, Ong Phước Thịnh, Võ Văn Thắng, Kim Bảo Giang, Nguyễn Thuỳ Dương. Chương III: Tính toán cỡ mẫu nghiên cứu. Trong: Hoàng Văn Minh, Lưu Ngọc Hoạt, eds. Phương pháp chọn mẫu và tính toán cỡ mẫu trong nghiên cứu khoa học sức khoẻ. Trường Đại học Y tế Công cộng; 2020: 22-68.
9. Munns CF, Shaw N, Kiely M, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab. 2016; 101(2): 394-415. doi:10.1210/jc.2015-2175.
10. Dissanayake S, Tennekoon S, Gaffoor S, Liyanage G. Vitamin D deficiency in dengue hemorrhagic fever and dengue shock syndrome among Sri Lankan children: a case-control study. Wang R, ed. J Trop Med. 2021; 2021: 4173303. doi:10.1155/2021/4173303.
11. Nguyen TM, Nguyen HT, Ngo MNQ, et al. Epidemiological characteristicộng sự of dengue among Vietnamese children in the 2017 dengue outbreak. Syst Rev Pharm. 2020; 11: 113-118.
12. Nguyễn Mậu Thạch, Nguyễn Đình Tuyến, Nguyễn Hữu Châu Đức, Đỗ Duy Thanh. Nghiên cứu đặc điểm dịch tễ học, lâm sàng và các yếu tố tiên lượng nặng ở bệnh nhi sốt xuất huyết Dengue tại bệnh viện Sản - Nhi tỉnh Quảng Ngãi. Tạp chí Nhi khoa. 17(1): 16-23.
13. Verma J, Pankaj J, Singh A. Study on Association of Vitamin D Deficiency and Severity of Symptoms in Dengue Patients Admitted in A Tertiary Care Centre in North India: A Cross-Sectional Study. International Journal of Toxicological and Pharmacological Research. 2024; 14(5); 33-41.