Factors Associated with Postnatal Cytomegalovirus Infection in Preterm Infants
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Abstract
Our study was conducted at the Neonatal Intensive Care Unit of the National Children’s Hospital, Hanoi, Vietnam, from January 2022 to May 2023. A total of 170 preterm infants born at < 32 weeks’ gestation without evidence of congenital CMV infection were then tested for postnatal CMV infection by PCR testing of urine specimens collected after three weeks of age. There were 72 patients tested positive and 98 tested negative. Maternal and perinatal characteristics-including maternal age, ethnicity, educational level, occupation, pregnancy-related comorbidities, and mode of delivery-did not differ significantly between groups. Compared with non-infected infants, those with postnatal CMV infection had significantly lower gestational age (27.60 vs. 28.18 weeks; p = 0.015) and birth weight (1018,47 g vs. 1132,24 g; p = 0.008), received more packed red blood cell transfusions (p = 0.028), and experienced a longer duration of unpasteurized breast-milk feeding (44.94 vs. 35.41 days; p < 0.001). In multivariate logistic regression analysis, only the duration of breast-milk feeding remained an independent associated factor for postnatal CMV infection (adjusted odds ratio - aOR = 1.033; 95 % CI: 1.011 - 1.057; p = 0.004). These findings indicate that transmission via unprocessed breast milk is the principal determinant of postnatal CMV infection in this cohort of very preterm infants.
Article Details
Keywords
Preterm, cytomegalovirus
References
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