Serum NT-ProBNP concentration in healthy children
Main Article Content
Abstract
The study was conducted to determine serum NT-ProBNP concentration in healthy children. A descriptive cross – sectional study was conducted to measure the concentration of NT-ProBNP serum in 272 healthy children from 1 day to 15 years old during their regular health check-up at the National Children’s Hospital from April 2018 to October 2019. The median NT-ProBNP concentration of the research participants is 31 pg/ml, (min-max: 19-57.6) pg / ml. The highest concentration of NT-ProBNP was under 1 month of age and then decreased with age (r = -0.352; p < 0.05). There was no difference in NT-prBNP concentration between male and female (p > 0.05). NT-ProBNP levels in healthy children were negatively correlated with age and did not depend on gender.
Article Details
Keywords
NT-ProBNP, children, healthy.
References
2. Mair J. Clinical significance of pro-B-type natriuretic peptide glycosylation and processing. Clinical Chemistry. 2009; 55(3), 394–397.
3. Troughton R, Michael Felker G, and Januzzi J.L. Natriuretic peptide-guided heart failure management. European Heart Journal. 2014; 35(1), 16–24.
4. Hoàng Anh Tiến, Huỳnh Văn Minh, Lê Thị Phương Anh. Đánh giá sự biến đổi nồng độ NT-proBNP ở đợt cấp của bệnh nhân suy tim mạn. Tạp chí Y học Việt Nam. 2005; 41, 650–663.
5. Nir A, Bar-Oz B, Perles Z, et al. N-terminal pro-B-type natriuretic peptide: reference plasma levels from birth to adolescence. Elevated levels at birth and in infants and children with heart diseases. Acta Paediatrica. 2004; 93(5), 603–607.
6. Nir A, Lindinger A, Rauh M, et al. NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies. Pediatric Cardiology. 2009; 30(1), 3–8.
7. Mir T.S, Marohn S, Läer S, et al. Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure. Pediatrics. 2002; 110(6), 76.
8. Sai Li, MSa,b, Zhenghui Xiao, MDc, Liping Li, et al. Establishment of normal reference values of NT-proBNP and its application in diagnosingacute heart failure in children with severe handfood and mouth disease. Medicine. 2018; 97(36):e12218.
9. Bộ Y Tế. Định lượng NT-ProBNP. Hướng dẫn quy trình kỹ thuật chuyên ngành Hóa sinh.Nhà Xuất Bản Học, Hà Nội. 2014; 337–340.
10. Geiger R, Hammerer-Lercher A, Url C, et al. NT-proBNP concentrations indicate cardiac disease in pediatric patients. International Journal of Cardiology. 2007; 123(1), 63–65.
11. Sugimoto M, Manabe H, Nakau K, et al. The role of N-terminal pro-B-type natriuretic peptide in the diagnosis of congestive heart failure in children. - Correlation with the heart failure score and comparison with B-type natriuretic peptide. Official Journal of the Japanese Circulation Society. 2010; 74(5), 998–1005.
12. Theo Deepak K Gupta , Lori B Daniels, Susan Cheng. “Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis). American Journal of Cardiology. 2017; 120(6), 1008-1015.
13. Menghong Deng, Chunwang Lin, Wen Tang, et al. Plasma N-terminal pro-B-type natriuretic peptide: selecting the optimal heart failure marker in children of age up to 18 years. International Journal of Clinical and Experimental Pathology. 2016; 9(10), 10756–10762.
14. G.Koerbin,W.P.Abhayaratna,J.M.Potter, et al. NTproBNP concentrations in healthy children. Clinical Biochemistry. 2012; 45 (15), 1158-1160.
15. Fradley M.G, Larson M.G, Cheng S, et al. Reference Limits for N-terminal-pro-B-type Natriuretic Peptide in Healthy Individuals (From the Framingham Heart Study). American Journal of Cardiology. 2011; 108(9), 1341–1345.
16. Hyun Su Kim and Hee Joung Choi. N-terminal pro-B-type natriuretic peptidelevels in children: comparison in cardiacand non-cardiac diseases. Cardiology in the Young. 2020; 30(4), pp 500 – 504.