Association between XRCC3gene polymorphism RS1799794and ovarian cancer risk
Main Article Content
Abstract
Ovarian cancer is one of the most common types of gynecological malignancies. Deficiencies of DNA damage recognition and repair system play a significant role in increasing the risk of cancer. The gene XRCC3 involves in HRR (homologous recombinational repair) for DBSs (double strand breaks of DNA), so its polymorphisms and mutations are associated with cancer risk. The study aimed to study the XRCC3 rs1799794 polymorphism associated with the risk of ovarian cancer in Vietnamese females. This case-control studied genotyping of XRCC3 polymorphism rs1799794 in 380 ovarian cancer patients and 380 age-matched controls, then analyzed the distributions of the genotypic or allelic frequencies and their association with ovarian cancer risk. The results showed the distributions of genotype AA, AG and GG are 25.8%, 55.3%, 18.9% for the study group and 31.3%, 45.3%, 23.4% for the control group, respectively (p = 0.022).
Article Details
Keywords
Ovarian cancer, XRCC3gene, rs1799794, a4541g, polymorphism
References
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