43. Nghiên cứu tác dụng của chế phẩm picositol trên mô hình hội chứng buồng trứng đa nang thực nghiệm

Abstract

The study was conducted to evaluate the effects of Picositol on Wistar rats induced with polycystic ovary syndrome (PCOS) by letrozole. PCOS was induced in female Wistar rats by oral administration of letrozole at 1 mg/kg/day for 21 consecutive days. After the induction phase, the rats were randomly assigned to treatment groups including: control group, positive control group 1 (metformin), positive control group 2 (clomiphene), and two groups receiving Picositol at 0.12 sachet/kg/day and 0.24 sachet/kg/day, respectively. All treatments were administered orally for 15 consecutive days. Throughout the experiment, daily vaginal smear tests were performed to monitor estrous cycle phases. The following parameters were assessed: body weight, serum lipid profile, blood glucose levels, and ovarian histopathological evaluation. The results demonstrated that Picositol, at both doses, significantly reduced serum lipid levels meanwhile the higher dose increased HDL-C level. Additionally, Picositol reduced blood glucose levels and improved ovarian histopathology comparably to the positive control drugs. These findings suggest that Picositol has therapeutic potential in the management of polycystic ovary syndrome (PCOS) in the animal experimental model.