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Published: 2025-10-31
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DOI: https://doi.org/10.52852/tcncyh.v195i10.3944
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Vol. 195 No. 10 (2025)
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Thu, B. T. H., Vinh, D. T., Tịnh, T. T., Đào, T. T. B., Trung, N. V., Du, N. V., Huỳnh, Đào V., Hoàng, N. K., & Đạt, T. H. (2025). 6. Effect of high-intensity inspiratory muscle training in patients with heart failure with ejection fraction > 40%: A randomized controlled trial. Journal of Medical Research, 195(10), 49-60. https://doi.org/10.52852/tcncyh.v195i10.3944

6. Effect of high-intensity inspiratory muscle training in patients with heart failure with ejection fraction > 40%: A randomized controlled trial

Bui Thi Hoai Thu, Duong The Vinh, Tran Thanh Tinh, Tran Thi Bich Dao, Nguyen Van Trung, Nguyen Van Du, Dao Van Huynh, Nguyen Khac Hoang, Tran Huu Dat

Main Article Content

Abstract

Inspiratory muscle weakness (IMW) is correlated with impaired exercise tolerance and poor prognosis in heart failure with preserved (HF-pEF) and mildly reduced ejection fraction (HF-mrEF). Inspiratory muscle training (IMT) has shown promise in improving IMW and functional capacity, but evidence for high-intensity IMT (HI-IMT) remains limited, particularly in HF-pEF and HF-mrEF. This study sought to assess the effects of an 8-weeks HI-IMT program on inspiratory muscle strength, exercise capacity, echocardiographic parameters, and quality of life (QoL) in patients with HF-pEF and HF-mrEF. A randomized, double-blind, controlled trial with a prospective design was performed with 40 patients. Participants were allocated at random to either the HI-IMT group or the control group. Unfavorable outcomes were also monitored, including arrhythmia, fainting, and syncope. The HI-IMT group demonstrated clinically relevant improvements compared to the control group in VO2peak, 6MWT, and MIP. QoL improved significantly in the Role Functioning/Physical and General Mental Health domains, while other domains showed similar changes between groups. No adverse event was reported. These findings support HI-IMT as a safe and effective intervention for improving outcomes in heart failure. Further studies are warranted to confirm these benefits and evaluate their long-term sustainability.

Article Details

Keywords

Inspiratory muscle training, heart failure, exercise capacity

References

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