49. Evaluation of acute toxicity and effects of TD.TN hard capsule on memory improvement in experimental animals
Main Article Content
Abstract
Dementia severely affects patients' daily functioning and quality of life. This study was conducted to determine the acute toxicity and memory-enhancing effects of Nobel tri nao hard capsules (TD.TN) in experimental animals. The acute toxicity study of TD.TN was performed on Swiss mice following WHO guidelines, and the LD50 was estimated using the Litchfield–Wilcoxon method. The memory-enhancing effects of TD.TN were evaluated using scopolamine-induced memory impairment models: the active avoidance test and the rotarod assay. Animals were divided into five groups: a control group, a model group, a group treated with donepezil, and two groups treated with TD.TN at a clinically equivalent dose and at three times the clinical dose. Results showed that TD.TN mice group administered up to 85.31 g/kg exhibited no sign of acute toxicity, and the LD50 of the formulation could not be determined. TD.TN significantly increased the time on the rotarod, and improved latency and the number of successful avoidances in the active avoidance model compared to the model group.
Article Details
Keywords
Nobel tri nao, acute toxicity, memory enhancement, rotarod, active avoidance
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