46. Anti-fatigue effects of Eatwellb solution in experimental animals

Tran Thanh Tung, Dinh Thi Tuyet Lan, Pham Bui Tung Lam, Nguyen Thi Thanh Loan

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Abstract

This study aimed to evaluate the anti-fatigue effects of EATWELLB solution in experimental animals. Fatigue was induced in Swiss mice through daily swimming and Rotarod tests for one week. Following fatigue induction, the mice were orally administered either sulbutiamine at 96 mg/kg/day or EATWELLB solution at 3.6 and 10.8 ml/kg/day for three consecutive weeks. The anti-fatigue effects of EATWELLB were confirmed through a rotarod performance test, measuring the mice grip strength force a forced swimming test, and determination of biochemical parameters. Our results indicated that treatment with EATWELLB at both doses significantly increased grip strength force and prolonged riding and swimming times compared to the model group. Additionally, EATWELLB increased blood glucose levels and reduced blood urea nitrogen (BUN), as well as serum AST and ALT. Furthermore, EATWELLB at both doses significantly increased food intake compared to the model group. These findings suggest that the EATWELLB solution exerts anti-fatigue effects in experimental animals.

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References

1. Cortes Rivera M, Mastronardi C, Silva-Aldana CT, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics. 2019; 9(3): 91.
2. Luo C, Xu X, Wei X, et al. Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms. Pharmacological Research. 2019; 148: 104409.
3. Yu W, Song C, Lei Z, et al. Anti-fatigue effect of traditional Chinese medicines: A review. Saudi Pharmaceutical Journal. 2023; 31(4): 597-604.
4. Lee MC, Hsu YJ, Shen SY, et al. A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial. International journal of medical sciences. 2023; 20(10): 1272.
5. Zou JM, Zhu QS, Liang H, et al. Lysine deprivation regulates Npy expression via GCN2 signaling pathway in mandarin fish (Siniperca chuatsi). International Journal of Molecular Sciences. 2022; 23(12).
6. Shay NF, Mangian HF. Neurobiology of zinc-influenced eating behavior. The Journal of nutrition. 2000; 130(5): 1493S-1499S.
7. Cloetens L, Ulmius M, Johansson-Persson A, et al. Role of dietary beta-glucans in the prevention of the metabolic syndrome. Nutrition reviews. 2012; 70(8): 444-458.
8. Recharla N, Kim D, Ramani S, et al. Dietary multi-enzyme complex improves in vitro nutrient digestibility and hind gut microbial fermentation of pigs. PloS one. 2019; 14(5): e0217459.
9. Trần Thanh Tùng, Nguyễn Thị Thanh Loan. Nghiên cứu độc tính cấp và bán trường diễn của ung dịch uống EATWELLB trên động vật thực nghiệm. Tạp chí Nghiên cứu Y học. 2024; 178(5): 239-249.
10. Zhong L, Zhao L, Yang F, et al. Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice. Journal of the International Society of Sports Nutrition. 2017; 14(1): 15.
11. Yan K, Gao H, Liu X, et al. Establishment and identification of an animal model of long-term exercise-induced fatigue. Frontiers in Endocrinology. 2022; 13: 915937.
12. Lee SM, Kim YH, Kim YR, et al. Anti-fatigue potential of Pinus koraiensis leaf extract in an acute exercise-treated mouse model. Biomedicine & Pharmacotherapy. 2022; 153: 113501.
13. Fu J, Liu S, Li M, et al. Optimal fasting duration for mice as assessed by metabolic status. Scientific Reports. 2024; 14(1): 21509.
14. Chi A, Li H, Kang C, et al. Anti-fatigue activity of a novel polysaccharide conjugates from Ziyang green tea. International Journal of Biological Macromolecules. 2015; 80: 566-572.
15. Kawamura T, Muraoka I. Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint. Antioxidants. 2018; 7(9): 119.
16. Fisher M, Krilov LR, Ovadia M. Chronic fatigue syndrome and eating disorders: concurrence or coincidence? International Journal of Adolescent Medicine and Health. 2002; 14(4): 307-16.
17. Liguori S, Moretti A, Paoletta M, et al. Role of Magnesium in skeletal muscle health and neuromuscular diseases: A scoping review. International Journal of Molecular Sciences. 2024; 25(20): 11220.
18. Choi SK, Baek SH, Choi SW. The effects of endurance training and thiamine supplementation on anti-fatigue during exercise. Journal of Exercise Nutrition & Biochemistry. 2013; 17(4): 189.
19. Nagaraj S. Loss of Appetite in Adult Patients: Effectiveness and safety of an appetite stimulating medication in an open-label, investigator-initiated study in India. Journal of nutrition and metabolism. 2022; 2022(1): 2661912.