36. Một số đặc điểm lâm sàng và cận lâm sàng của mày đay mạn tính ở người cao tuổi và người trưởng thành

Abstract

This cross-sectional, observational study was conducted on 210 elderly patients (aged 60 years and older) diagnosed with chronic urticaria (CU) and 1210 CU adult patients (aged 16 to 60 years old) at the Urticaria Clinic, National Hospital of Dermatology and Venereology, Hanoi, from February 2023 to July 2025 to describe and analyze the differences in clinical and laboratory characteristics of CU in the elderly and adults. the frequency of CU in the elderly group was 84.8%, higher than the adult group at 75.5%; but the rate of induced CU was lower (4.3% and 8.3%; p = 0.012). Female were predominant in both the elderly and adult CU groups (p < 0.05). Angioedema was observed in 23.3% of the elderly CU patients, siginifcanly lower than the adult group (30.3%) (p < 0.05). The elderly group had a significantly higher rate of commorbidities, especially metabolic (29.5% and 2.4%; p < 0.001), cardiovascular (22.4% and 2.1%; p < 0.001), musculoskeletal (5.7% and 1.2%; p < 0.001), thyroid (8.6% and 5.1%; p = 0.045) and autoimmune disorders (2.4% and 0.5%; p = 0.015). Regarding laboratory investigations, the elderly group had a higher 1-hour erythrocyte sedimentation rate, higher CRP, anti-TPO and ANA concentrations (all p < 0.05), while total IgE concentrations and the rate of positive autologous serum tests revealed comparable. In conclusion, CU in the elderly has some unique characteristics in terms of CU body ratio, angioedema ratio, comorbidities in metabolic disorders, inflammatory and autoimmune manifestations.