Article Sidebar

PDF (Tiếng Việt)
Published: 2025-12-30
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v197i12.4081
Issue
Vol. 197 No. 12 (2025)
Section
Các bài báo
How to Cite
Quyên, H. T. T., Lan, V. T. N., Hằng, P. T., & Trinh, N. T. N. (2025). Failure of NSAID Therapy in Primary Dysmenorrhea: A Cohort Study at Hung Vuong Hospital. Journal of Medical Research, 197(12), 337-349. https://doi.org/10.52852/tcncyh.v197i12.4081

Failure of NSAID Therapy in Primary Dysmenorrhea: A Cohort Study at Hung Vuong Hospital

Huynh Thuy Thao Quyen, Vuong Thi Ngoc Lan, Phan Thi Hang, Nguyen Thi Ngoc Trinh

Main Article Content

Abstract

This study aimed to estimate the short-term failure rate of non-steroidal anti-inflammatory drugs (Ibuprofen 400mg) in treating primary dysmenorrhea, and identify associated factors. A prospective cohort study involving 206 women of reproductive age with primary dysmenorrhea was conducted at Hung Vuong Hospital from December 2024 to April 2025. Pain was assessed using the Visual Analog Scale (VAS) before treatment, after 3 days, and after 3 menstrual cycles. Treatment failure was defined as a < 2-point reduction in VAS after 3 days. The treatment failure rate after 3 days and 3 months of NSAID use was 16.02%, and 2.98%, respectively. Factors associated with treatment failure included: women with normal BMI had a lower risk of failure compared to underweight women (RR = 0.48; p = 0.014); greater menstrual blood loss was associated with a higher risk of treatment failure (RR = 1.11; p < 0.001); and treatment adherence was associated with a significantly lower risk of failure (RR = 0.41; p < 0.001). NSAIDs remain a feasible and effective first-line option in the clinical management of primary dysmenorrhea. Certain factors associated with treatment failure should be identified early to individualize therapy, minimize symptoms, and improve patients’ quality of life.

Article Details

Keywords

Primary dysmenorrhea, non-steroidal anti-inflammatory drugs, treatment failure, visual analog scale, cohort studies

References

1. Oladosu FA, Tu FF, Hellman KM. Nonsteroidal antiinflammatory drug resistance in dysmenorrhea: epidemiology, causes, and treatment. Am J Obstet Gynecol. 2018; 218(4): 390-400. doi:10.1016/j.ajog.2017.08.108.
2. Kirmizigil B, Demiralp C. Effectiveness of functional exercises on pain and sleep quality in patients with primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2020; 302(1): 153-163. doi:10.1007/s00404-020-05579-2.
3. Cepeda MS, Africano JM, Polo R, Alcala R, Carr DB. What decline in pain intensity is meaningful to patients with acute pain? Pain. 2003; 105(1-2): 151-157. doi:10.1016/s0304-3959(03)00176-3.
4. Aceituno-Gómez J, Avendaño-Coy J, Criado-Álvarez JJ, et al. Correlation between three assessment pain tools in subacromial pain syndrome. Clin Rehabil. 2021; 35(1): 114-118. doi:10.1177/0269215520947596.
5. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care & Research. 2011; 63(S11). doi:10.1002/acr.20543.
6. Higham JM, O’Brien PMS, Shaw RW. Assessment of menstrual blood loss using a pictorial chart. BJOG. 1990; 97(8): 734-739. doi:10.1111/j.1471-0528.1990.tb16249.x.
7. Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Gynaecology and Fertility Group, ed. Cochrane Database of Systematic Reviews. 2015; 2015 (7). doi:10.1002/14651858.CD001751.pub3.
8. Nie W, Xu P, Hao C, Chen Y, Yin Y, Wang L. Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis. Medicine. 2020; 99(19): e19881. doi:10.1097/MD.0000000000019881.
9. Delgado DA, Lambert BS, Boutris N, et al. Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults. JAAOS Glob Res Rev. 2018; 2(3): e088. doi:10.5435/JAAOSGlobal-D-17-00088.
10. Randall DJ, Zhang Y, Li H, Hubbard JC, Kazmers NH. Establishing the Minimal Clinically Important Difference and Substantial Clinical Benefit for the Pain Visual Analog Scale in a Postoperative Hand Surgery Population. Journal of Hand Surgery. 2022; 47(7): 645-653. doi:10.1016/j.jhsa.2022.03.009.
11. Zahradnik HP, Hanjalic-Beck A, Groth K. Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review. Contraception. 2010; 81(3): 185-196. doi:10.1016/j.contraception.2009.09.014.
12. Fernández-Martínez E, Onieva-Zafra MD, Parra-Fernández ML. Lifestyle and prevalence of dysmenorrhea among Spanish female university students. Palazón-Bru A, ed. PLoS ONE. 2018; 13(8): e0201894. doi:10.1371/journal.pone.0201894.
13. Wu L, Zhang J, Tang J, Fang H. The relation between body mass index and primary dysmenorrhea: A systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica. 2022; 101(12): 1364-1373. doi:10.1111/aogs.14449.