Article Sidebar

PDF (Tiếng Việt)
Published: 2025-10-31
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52852/tcncyh.v195i10.4093
Issue
Vol. 195 No. 10 (2025)
Section
Các bài báo
How to Cite
Giang, Đào T., Lâm, H. K., & Hoa, N. P. A. (2025). 16. Post - Kasai surgery outcomes in children with biliary atresia at Vietnam National Children’s Hospital, 2019 - 2024. Journal of Medical Research, 195(10), 150-158. https://doi.org/10.52852/tcncyh.v195i10.4093

16. Post - Kasai surgery outcomes in children with biliary atresia at Vietnam National Children’s Hospital, 2019 - 2024

Dao Thi Giang, Hoang Kim Lam, Nguyen Pham Anh Hoa

Main Article Content

Abstract

This study aimed to evaluate post-Kasai outcomes in infants with biliary atresia (BA) at the Vietnam National Children’s Hospital from 2019 to 2024. A descriptive study was conducted on 222 children with biliary atresia who underwent Kasai surgery, with a median follow-up of 22.7 months (range: 6.0 - 76.4 months). Native liver survival at 2 and 5 years was 80.5% and 68.8%, respectively. Common postoperative complications were cholangitis (71.6%), esophageal varices (49.5%), upper gastrointestinal bleeding (20.3%), and ascites (18.0%), predominantly occurring early and associated with increased risk of mortality or liver transplantation. Esophageal varices correlated with lower platelet counts and higher APRI scores, with median values of 125 G/L and 3.6, respectively. Patients with high postoperative PELD scores require close monitoring due to their high risk of mortality or need for liver transplantation.

Article Details

Keywords

Biliary atresia, portal hypertension, liver transplantation

References

1. Ando H, Inomata Y, Iwanaka T, et al. Clinical practice guidelines for biliary atresia in Japan: A secondary publication of the abbreviated version translated into English. J Hepato-Biliary-Pancreat Sci. 2021; 28(1): 55-61.
2. Chung PHY, Zheng S, Tam PKH. Biliary atresia: East versus west. Semin Pediatr Surg. 2020; 29(4): 150950.
3. Schreiber RA, Harpavat S, Hulscher JBF, et al. Biliary Atresia in 2021: Epidemiology, Screening and Public Policy. J Clin Med. 2022; 11(4): 999.
4. Suominen JS, Lampela H, Heikkilä P, et al. APRi predicts native liver survival by reflecting portal fibrogenesis and hepatic neovascularization at the time of portoenterostomy in biliary atresia. J Pediatr Surg. 2015; 50(9): 1528-1531.
5. Davenport M, Makin E, Ong EG, et al. The Outcome of a Centralization Program in Biliary Atresia: Twenty Years and Beyond. Ann Surg. 2025; 281(4): 608-614.
6. Bạch Thị Ly Na, (2016). Nhận xét một số biến chứng thường gặp và kết quả điều trị bệnh nhân teo mật bẩm sinh sau phẫu thuật Kasai tại bệnh viện Nhi Trung ương. Luận văn Thạc sĩ Y học.
7. Sv M, R A, As L. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation. Transplantation. 2002; 74(2).
8. Ct W, Jk G, Rj F, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatol Baltim Md. 2003; 38(2).
9. Lien TH, Chang MH, Wu JF, et al. Effects of the infant stool color card screening program on 5-year outcome of biliary atresia in Taiwan. Hepatol Baltim Md.
10. Kelley-Quon LI, Shue E, Burke RV, et al. The Need for Early Kasai Portoenterostomy: A Western Pediatric Surgery Research Consortium Study. Pediatr Surg Int. 2022; 38(2): 193-199.
11. Shneider BL, Magee JC, Karpen SJ, et al. Total Serum Bilirubin within Three Months of Hepatoportoenterostomy Predicts Short-term Outcomes in Biliary Atresia. J Pediatr. 2016; 170: 211-217.e2.
12. Degtyareva A, Razumovskiy A, Kulikova N, et al. Long-Term Effects of Kasai Portoenterostomy for Biliary Atresia Treatment in Russia. Diagnostics. 2020; 10(9): 686.
13. Gad EH, Kamel Y, Salem TAH, et al. Short- and long-term outcomes after Kasai operation for type III biliary atresia: Twenty years of experience in a single tertiary Egyptian center-A retrospective cohort study. Ann Med Surg. 2021; 62: 302-314.
14. Chen SY, Lin CC, Tsan YT, et al. Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy. BMC Pediatr. 2018; 18: 119.
15. Liu J, Dong R, Chen G, et al. Risk factors and prognostic effects of cholangitis after Kasai procedure in biliary atresia patients: A retrospective clinical study. J Pediatr Surg. 2019; 54(12): 2559-2564.
16. Poddar U, Samanta A, Sarma MS, et al. How to suspect the presence of high-risk esophageal varices and when to start endoscopic surveillance in children with biliary atresia? J Gastroenterol Hepatol. 2023; 38(9): 1610-1617.
17. Chang CCH, Bryce CL, Shneider BL, et al. Accuracy of the Pediatric End-stage Liver Disease Score in Estimating Pretransplant Mortality Among Pediatric Liver Transplant Candidates. JAMA Pediatr. 2018; 172(11): 1070-1077.