The value of free beta HCGserum in hydatidiform mole, normal pregnancy and trophoblastic neoplasia

Mai Trong Dung, Pham Huy Hien Hao

Main Article Content

Abstract

The purpose of this study is to investigate the value of free beta hCG serum in normal pregnancy, hydatidiform mole and trophoblastic neoplasia and to determine the role of free beta hCG serum for differential diagnosis of normal pregnancy, hydatidiform mole and trophoblastic neoplasia. This is a cross - descriptive study conducted in 191 cases of hydatidiform mole, 86 cases of normal pregnancy and 33 cases of trophoblastic neoplasia treated at the National Obstetrics and Gynecology Hospital. Results showed that the value of free beta hCG in hydatidiform mole serum is 432.6 ± 443.0 ng/ml; in normal pregnancy is 71.2 ± 47.6 ng/ml; in trophoblastic neoplasia serum is 121.7 ± 154.7ng/ml. In conclusion, the value of free beta hCG in hydatidiform mole is higher than normal pregnancy and is significant for differential diagnosis. The value of free beta hCG have little significance to distinguish between trophoblastic neoplasia and hydatidiform mole or between trophoblastic neoplasia normal pregnancy.

Article Details

References

1. Sun SY, Melamed A, Goldstein DP et al. Changing presentation of complete hydatidiform mole at the New England Trophoblastic Disease Center over the past three decades: does early diagnosis alter risk for gestational trophoblastic neoplasia? Gynecol Oncol. 2015;138 (1):46 - 49.
2. Braga A, Moraes V, Maesta I et al. Changing Trends in the Clinical Presentation and Management of Complete Hydatidiform Mole Among Brazilian Women. Int J Gynecol Cancer. 2016;26 (5):984 - 990,
3. Phạm Huy Hiền Hào. Vai trò của beta hCG huyết thanh trong theo dõi sau nạo trứng, điều trị u nguyên bào nuôi và một số yếu tố liên quan đến tái phát. Luận án Tiến sĩ Y học. 2004; Trường Đại học Y Hà Nội.
4. Ngan HYS, Seckl MJ, Berkowitz RS et al. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018;143 (2):79 - 85.
5. Nguyễn Văn Thắng. Thực trạng bệnh u nguyên bào nuôi ở Bệnh viện Phụ sản Trung ương và hiệu quả các giải pháp quản lý bệnh nhân ở cộng đồng. Luận án Tiến sĩ Y học. 2020; Học viện Quân Y.
6. Nguyễn Quốc Tuấn. Nghiên cứu về một số đặc điểm thường gặp trên bệnh nhân chửa trứng và các yếu tố liên quan đến biến chứng. Luận án Tiến sỹ Y học. 2003; Trường Đại học Y Hà Nội.
7. Savage PM, Sita - Lumsden A, Dickson S et al. The relationship of maternal age to molar pregnancy incidence, risks for chemotherapy and subsequent pregnancy outcome. J Obstet Gynaecol. 2013;33 (4):406 - 411.
8. Lertkhachonsuk AA. Complete hydatidiform mole. Change in profile over three decades. The Journal of reproductive medicine. 2012;57:470 - 474.
9. Ozturk M, Berkowitz R, Goldstein D et al. Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease. American Journal of Obstetrics and Gyneco logy. 1988;158 (1):193 - 198.
10, Khazaeli MB, Buchina ES, Pattillo RA et al. Radioi mmunoassay of free ß - subunit of human chorionic gonadotropin in diagnosis of high - risk and low - risk gestational trophoblastic disease. American Journal of Obstetrics and Gyneco logy. 1989;160 (2):444 - 449.
11. Tang YP, Wu YS, Yin AH et al. Determination of median levels of the free beta subunit of human chorionic gonadotropin in women from Mainland China using a new time - resolved fluoroi mmunoassay. Clin Chem Lab Med. 2010;48 (1):109 - 114.
12. Shiefa S, Amargandhi M, Bhupendra J et al. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP - A and Free beta - hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. Jan 2013;28 (1):3 - 12.