Subchronic toxicity evaluation of persea americana extract in experimental animals
Main Article Content
Abstract
The research evaluated the sub-chronic toxicity of Persea americana extract through oral administration in animal experiment. The sub-chronic toxicity study was conducted by the recommendation of WHO in Wistar rats with oral doses of 0.24 g/kg/day and 0.72 g/kg/day for 30 consecutive days. As a result, oral administration of Persea americana extract at 0.24 g/kg/day and 0.72 g/kg/day did not have any affect on general condition, body weight, and hematological parameters. However, after 30 days of administration, changes of hepato-renal functions and histopathological structures of the liver and kidney were observed in groups treated with Persea americana extract. On micro-histopathological images, both doses of Persea americana extract caused mild to moderate degeneration of liver cells, while mild degeneration was observed in the group treated with high-dose extract. Therefore, it is essential to assess liver and kidney function when using Persea americana extract in subsequent studies.
Article Details
Keywords
Persea americana extract, sub-chronic toxicity, Wistar rat
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