Characteristics of the ANRIL rs2383207 polymorphism and its association with lipid parameters among patients with chronic coronary syndrome in Can Tho city

Abstract

The rs2383207 polymorphism of the ANRIL gene has attracted considerable attention due to its association with coronary artery disease, but its effect on lipid metabolism remains unclear. In this cross-sectional study, 66 newly diagnosed patients with chronic coronary syndrome from three hospitals in Can Tho (June 2024 – May 2025) were analyzed for rs2383207 genotypes and lipid profiles. Most patients were ≥ 60 years (81.8%) and male (59.1%), with common risk factors including hypertension (90.9%), sedentary lifestyle (78.8%), and dyslipidemia (69.7%). The G allele was predominant at 65.9% and GA was the most frequent genotype at 68.2% while no AA genotype was observed. Carriers of the G allele had higher LDL-c (2.85 ± 1.28 vs. 2.20 ± 0.90 mmol/L; p < 0.001) and a higher risk of elevated LDL-c (OR = 2.6; 95% CI: 1.16 – 5.6; p = 0.024). At the genotype level, the GG group had higher total cholesterol (p = 0.021) and LDL-c (p < 0.001), as well as a higher risk of elevated total cholesterol (OR = 7.0; 95% CI: 1.6 – 30.8) and LDL-c (OR = 1.67; 95% CI: 1.31 – 2.12). No statistically significant differences were observed for triglycerides or HDL-c. These findings indicate that the G allele and GA genotype of the rs2383207 ANRIL polymorphism are common in patients with chronic coronary syndrome and are associated with elevated total cholesterol and LDL-c levels.