Retinal lesion characteristics and associated factors in hypertensive patients at E Hospital in 2025

Pham Dieu Linh, Nguyen Thi Lan Anh, Nguyen Quynh Hoa, Duong Thi Hue

Main Article Content

Abstract

Hypertensive retinopathy (HR) is one of the common ocular complications of systemic hypertension and reflects the severity of systemic vascular damage, including stroke and cardiovascular disease. This study aimed to describe retinal lesions associated with hypertension and to evaluate the relationship between hypertensive retinopathy and selected risk factors. A cross-sectional descriptive study was conducted on 306 eyes from 154 hypertensive patients at E Hospital from May to September 2025. Among 306 eyes examined, the prevalence of HR was 61.1%, with mild stage being predominant (46.7%). Generalized arteriolar narrowing was the earliest lesion observed. Risk factors significantly associated with HR included duration of hypertension longer than 10 years (OR = 3.615, 95% CI: 1.733 - 7.542, p < 0.0001) and unstable blood pressure control (OR = 5.238, 95% CI: 2.447 - 11.406, p < 0.0001). Moderate-stage HR increased the risk of stroke by 20-fold compared with the mild stage (95% CI: 2.283 - 176.944, p = 0.002).

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References

1. Hypertension. https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed May 1, 2025.
2. Hypertension Viet Nam 2023 country profile. https://www.who.int/publications/m/item/hypertension-vnm-2023-country-profile. Accessed May 1, 2025.
3. Wong TY, McIntosh R. Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality. British Medical Bulletin. 2005; 73-74(1): 57-70. doi:10.1093/bmb/ldh050.
4. Chen X, Liu L, Liu M, et al. Hypertensive Retinopathy and the Risk of Stroke Among Hypertensive Adults in China. Invest Ophthalmol Vis Sci. 2021; 62(9): 28. doi:10.1167/iovs.62.9.28.
5. Liew G, Xie J, Nguyen H, et al. Hypertensive retinopathy and cardiovascular disease risk: 6 population-based cohorts meta-analysis. International Journal of Cardiology Cardiovascular Risk and Prevention. 2023; 17:200180. doi:10.1016/j.ijcrp.2023.200180.
6. Wang Z, Feng L, Wu M, et al. Hypertensive retinopathy can predict stroke: A systematic review and meta-analysis based on observational studies. Journal of Stroke and Cerebrovascular Diseases. 2024; 33(11): 107953. doi:10.1016/j.jstrokecerebrovasdis.2024.107953.
7. Phạm Việt Bắc, Châu Ngọc Hoa. Khảo sát biến chứng võng mạc trên bệnh nhân tăng huyết áp bằng chụp hình màu đáy mắt. Tạp chí Y học Thành phố Hồ Chí Minh. 2011; 15(1): 88.
8. Gudayneh YA, Shumye AF, Gelaye AT, Tegegn MT. Prevalence of hypertensive retinopathy and its associated factors among adult hypertensive patients attending at Comprehensive Specialized Hospitals in Northwest Ethiopia, 2024, a multicenter cross-sectional study. Int J Retin Vitr. 2025; 11(1): 17. doi:10.1186/s40942-025-00631-2.
9. Chua J, Cheung CYL, Schmetterer L, Wong TY. Hypertensive Fundus Changes. In: Sheyman A, Fawzi AA, eds. Retinal Vascular Disease. Retina Atlas. Springer Nature Singapore; 2020: 85-97. doi:10.1007/978-981-15-4075-2_9.
10. Wong TY, McIntosh R. Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality. British Medical Bulletin. 2005; 73-74(1): 57-70. doi:10.1093/bmb/ldh050.
11. Klein R, Klein BE, Moss SE. The relation of systemic hypertension to changes in the retinal vasculature: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc. 1997; 95: 329-348; discussion 348-350.
12. Zhang Y, Zhao L, Li H, Wang Y. Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study. Exp Ther Med. Published online November 14, 2018. doi:10.3892/etm.2018.6967.
13. Wang JJ, Mitchell P, Leung H, Rochtchina E, Wong TY, Klein R. Hypertensive Retinal Vessel Wall Signs in a General Older Population: The Blue Mountains Eye Study. Hypertension. 2003; 42(4): 534-541. doi:10.1161/01.HYP.0000090122.38230.41.
14. Ong YT, Wong TY, Klein R, et al. Hypertensive Retinopathy and Risk of Stroke. Hypertension. 2013; 62(4): 706-711. doi:10.1161/HYPERTENSIONAHA.113.01414.