Factors associated with mortality in children undergoing continuous renal replacement therapy at Vietnam National Children Hospital
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Abstract
This study aimed to determine the mortality rate and identify factors associated with mortality in pediatric patients undergoing continuous renal replacement therapy (CRRT) at Vietnam National Children Hospital. A case series was conducted on 119 children who received CRRT in the Pediatric Intensive Care Unit between May 2023 and June 2024. The findings revealed a mortality rate of 47.9%. Factors significantly associated with mortality (p < 0.05) included septic shock, hypothermia, elevated Vasoactive-Inotropic Score (VIS), an increased number of organ failures, elevated blood lactate levels, and time to CRRT initiation after admission. Multivariate analysis identified the following as independent predictors of mortality: septic shock (OR = 3.14; 95% CI: 1.27 – 7.79), hypothermia (OR = 4.49; 95% CI: 1.20 – 16.73), number of organ failures (OR = 1.91; 95% CI: 1.21 – 3.02), blood lactate level (OR = 1.23; 95% CI: 1.11 – 1.37), and prolonged time to CRRT initiation (OR = 1.02; 95% CI: 1.00 – 1.04). These results underscore the importance of early recognition and aggressive management of septic shock, hypothermia, and multi-organ failure, as well as prompt initiation of CRRT, in order to improve outcomes in critically ill pediatric patients.
Article Details
Keywords
Continuous renal replacement therapy, mortality, risk factors, septic shock
References
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